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Holiday Rentals in Murphysboro

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50 rentals in Murphysboro.
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Reece Ridge Cabins. Enjoy A Relaxing, Quiet Stay At The Area's Premier Cabin., holiday rental in Murphysboro
Reece Ridge Cabins. Enjoy A Relaxing, Quiet Stay At The Area's Premier Cabin., holiday rental in Murphysboro
Reece Ridge Cabins. Enjoy A Relaxing, Quiet Stay At The Area's Premier Cabin., holiday rental in Murphysboro

Reece Ridge Cabins. Enjoy A Relaxing, Quiet Stay At The Area's Premier Cabin.

Holiday Rental House
6 bedrooms
2 bathrooms
Sleeps 12
Match: Sleeps
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Hilltop Retreat, a modernly-rustic getaway!, holiday rental in Murphysboro
Hilltop Retreat, a modernly-rustic getaway!, holiday rental in Murphysboro
Hilltop Retreat, a modernly-rustic getaway!, holiday rental in Murphysboro

Hilltop Retreat, a modernly-rustic getaway!

Holiday Rental House
3 bedrooms
2 bathrooms
Sleeps 10
Match: Sleeps
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Lovely Cozy Country Home Located In the Hills Of Southern Illinois, holiday rental in Murphysboro
Lovely Cozy Country Home Located In the Hills Of Southern Illinois, holiday rental in Murphysboro
Lovely Cozy Country Home Located In the Hills Of Southern Illinois, holiday rental in Murphysboro

Lovely Cozy Country Home Located In the Hills Of Southern Illinois

Holiday Rental House
2 bedrooms
1 bathroom
Sleeps 6
Match: Sleeps
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Mudline Lodging your premier Cabin Rental in Southern Illinois!, holiday rental in Murphysboro
Mudline Lodging your premier Cabin Rental in Southern Illinois!, holiday rental in Murphysboro
Mudline Lodging your premier Cabin Rental in Southern Illinois!, holiday rental in Murphysboro

Mudline Lodging your premier Cabin Rental in Southern Illinois!

Holiday Rental House
1 bedroom
1 bathroom
Sleeps 6
Match: Sleeps
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Creekside Valley: secluded, spacious home for 8!, holiday rental in Murphysboro
Creekside Valley: secluded, spacious home for 8!, holiday rental in Murphysboro
Creekside Valley: secluded, spacious home for 8!, holiday rental in Murphysboro

Creekside Valley: secluded, spacious home for 8!

Holiday Rental House
3 bedrooms
2 bathrooms
Sleeps 8
Match: Sleeps
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Water|Woods|Wildlife|Wonders Abound--The Only Lakefront Rental on Kinkaid in SNF, holiday rental in Murphysboro
Water|Woods|Wildlife|Wonders Abound--The Only Lakefront Rental on Kinkaid in SNF, holiday rental in Murphysboro
Water|Woods|Wildlife|Wonders Abound--The Only Lakefront Rental on Kinkaid in SNF, holiday rental in Murphysboro

Water|Woods|Wildlife|Wonders Abound--The Only Lakefront Rental on Kinkaid in SNF

Holiday Rental House
1 bedroom
1 bathroom
Sleeps 2
Match: Sleeps
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Carbondale 2017 Solar Eclipse shared rooms, holiday rental in Murphysboro
Carbondale 2017 Solar Eclipse shared rooms, holiday rental in Murphysboro
Carbondale 2017 Solar Eclipse shared rooms, holiday rental in Murphysboro

Carbondale 2017 Solar Eclipse shared rooms

Holiday Rental House
10 bedrooms
3 bathrooms
Sleeps 20
Match: Sleeps
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The Lab! Come stay in our brand new space., holiday rental in Murphysboro
The Lab! Come stay in our brand new space., holiday rental in Murphysboro
The Lab! Come stay in our brand new space., holiday rental in Murphysboro

The Lab! Come stay in our brand new space.

Condo/Apartment
3 bedrooms
1 bathroom
Sleeps 6
Match: Sleeps
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Heptagon Cottage-Timbered Retreat
No crazy checkout lists!, holiday rental in Murphysboro
Heptagon Cottage-Timbered Retreat
No crazy checkout lists!, holiday rental in Murphysboro
Heptagon Cottage-Timbered Retreat
No crazy checkout lists!, holiday rental in Murphysboro

Heptagon Cottage-Timbered Retreat No crazy checkout lists!

Holiday Rental House
4 bedrooms
5 bathrooms
Sleeps 12
Match: Sleeps
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Hilltop Retreat 2: Spacious, pond-front home for 12 near wine trail!, holiday rental in Murphysboro
Hilltop Retreat 2: Spacious, pond-front home for 12 near wine trail!, holiday rental in Murphysboro
Hilltop Retreat 2: Spacious, pond-front home for 12 near wine trail!, holiday rental in Murphysboro

Hilltop Retreat 2: Spacious, pond-front home for 12 near wine trail!

Holiday Rental House
4 bedrooms
2 bathrooms
Sleeps 12
Match: Sleeps
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Hilltop Cottage, holiday rental in Murphysboro
Hilltop Cottage, holiday rental in Murphysboro
Hilltop Cottage, holiday rental in Murphysboro

Hilltop Cottage

Holiday Rental House
2 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
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On the Lake & Wine Trail & a Perfect Getaway for15 With an ADA Suite!, holiday rental in Murphysboro
On the Lake & Wine Trail & a Perfect Getaway for15 With an ADA Suite!, holiday rental in Murphysboro
On the Lake & Wine Trail & a Perfect Getaway for15 With an ADA Suite!, holiday rental in Murphysboro

On the Lake & Wine Trail & a Perfect Getaway for15 With an ADA Suite!

Holiday Rental House
7 bedrooms
8 bathrooms
Sleeps 15
Match: Sleeps
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On the Shawnee Wine Trail

Holiday Rental House
0 bedrooms
2 bathrooms
Sleeps 4
Match: Sleeps
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How About Touring The Wineries This Spring? Stay at The Loft!, holiday rental in Murphysboro
How About Touring The Wineries This Spring? Stay at The Loft!, holiday rental in Murphysboro
How About Touring The Wineries This Spring? Stay at The Loft!, holiday rental in Murphysboro

How About Touring The Wineries This Spring? Stay at The Loft!

Holiday Rental House
3 bedrooms
2 bathrooms
Sleeps 8
Match: Sleeps
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Wine Trail Cabin, 2015 Built, Carbondale, Southern IL - Giant City State Park, holiday rental in Murphysboro
Wine Trail Cabin, 2015 Built, Carbondale, Southern IL - Giant City State Park, holiday rental in Murphysboro
Wine Trail Cabin, 2015 Built, Carbondale, Southern IL - Giant City State Park, holiday rental in Murphysboro

Wine Trail Cabin, 2015 Built, Carbondale, Southern IL - Giant City State Park

Holiday Rental House
2 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
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Giant City State Park, Shawnee Wine Trail, Carbondale IL, Shawnee Nat'l Forest, holiday rental in Murphysboro
Giant City State Park, Shawnee Wine Trail, Carbondale IL, Shawnee Nat'l Forest, holiday rental in Murphysboro
Giant City State Park, Shawnee Wine Trail, Carbondale IL, Shawnee Nat'l Forest, holiday rental in Murphysboro

Giant City State Park, Shawnee Wine Trail, Carbondale IL, Shawnee Nat'l Forest

Holiday Rental House
2 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
More info
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Easter in the Shawnee? Stay * The Barn, S.I.'s Largest Cabin on the Wine Trail!, holiday rental in Murphysboro
Easter in the Shawnee? Stay * The Barn, S.I.'s Largest Cabin on the Wine Trail!, holiday rental in Murphysboro
Easter in the Shawnee? Stay * The Barn, S.I.'s Largest Cabin on the Wine Trail!, holiday rental in Murphysboro

Easter in the Shawnee? Stay * The Barn, S.I.'s Largest Cabin on the Wine Trail!

Holiday Rental House
5 bedrooms
3 bathrooms
Sleeps 16
Match: Sleeps
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Dale House in the Trees- 1/2 mile to SIU, Flexible Check-in and Check-out!, holiday rental in Murphysboro
Dale House in the Trees- 1/2 mile to SIU, Flexible Check-in and Check-out!, holiday rental in Murphysboro
Dale House in the Trees- 1/2 mile to SIU, Flexible Check-in and Check-out!, holiday rental in Murphysboro

Dale House in the Trees- 1/2 mile to SIU, Flexible Check-in and Check-out!

Holiday Rental House
3 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
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Wine Trail Cabin - Carbondale, Southern Illinois - Giant City State Park, holiday rental in Murphysboro
Wine Trail Cabin - Carbondale, Southern Illinois - Giant City State Park, holiday rental in Murphysboro
Wine Trail Cabin - Carbondale, Southern Illinois - Giant City State Park, holiday rental in Murphysboro

Wine Trail Cabin - Carbondale, Southern Illinois - Giant City State Park

Holiday Rental House
2 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
More info
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Wine Trail Cabin, 2015 Built, Carbondale, Southern IL - Giant City State Park, holiday rental in Murphysboro
Wine Trail Cabin, 2015 Built, Carbondale, Southern IL - Giant City State Park, holiday rental in Murphysboro
Wine Trail Cabin, 2015 Built, Carbondale, Southern IL - Giant City State Park, holiday rental in Murphysboro

Wine Trail Cabin, 2015 Built, Carbondale, Southern IL - Giant City State Park

Holiday Rental House
2 bedrooms
1 bathroom
Sleeps 4
Match: Sleeps
More info
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Pine Cabin on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus, holiday rental in Murphysboro
Pine Cabin on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus, holiday rental in Murphysboro
Pine Cabin on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus, holiday rental in Murphysboro

Pine Cabin on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus

Holiday Rental House
1 bedroom
1 bathroom
Sleeps 4
Match: Sleeps
More info
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This Cobbleston Mid-Century Home Offers 4 Bedrooms on One Level, holiday rental in Murphysboro
This Cobbleston Mid-Century Home Offers 4 Bedrooms on One Level, holiday rental in Murphysboro
This Cobbleston Mid-Century Home Offers 4 Bedrooms on One Level, holiday rental in Murphysboro

This Cobbleston Mid-Century Home Offers 4 Bedrooms on One Level

Holiday Rental House
4 bedrooms
4 bathrooms
Sleeps 8
Match: Sleeps
More info
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Upscale, Luxurious Home with Lake View including Fountains!, holiday rental in Murphysboro
Upscale, Luxurious Home with Lake View including Fountains!, holiday rental in Murphysboro
Upscale, Luxurious Home with Lake View including Fountains!, holiday rental in Murphysboro

Upscale, Luxurious Home with Lake View including Fountains!

Holiday Rental House
4 bedrooms
3 bathrooms
Sleeps 8
Match: Sleeps
More info
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Pine Cabin on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus, holiday rental in Murphysboro
Pine Cabin on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus, holiday rental in Murphysboro
Pine Cabin on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus, holiday rental in Murphysboro

Pine Cabin on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus

Holiday Rental House
1 bedroom
1 bathroom
Sleeps 6
Match: Sleeps
More info
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Beautiful Views from Every Direction in This 4 Bedroom, 3 1/2 Bath Upscale Home!, holiday rental in Murphysboro
Beautiful Views from Every Direction in This 4 Bedroom, 3 1/2 Bath Upscale Home!, holiday rental in Murphysboro
Beautiful Views from Every Direction in This 4 Bedroom, 3 1/2 Bath Upscale Home!, holiday rental in Murphysboro

Beautiful Views from Every Direction in This 4 Bedroom, 3 1/2 Bath Upscale Home!

Holiday Rental House
4 bedrooms
4 bathrooms
Sleeps 8
Match: Sleeps
More info
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Peaceful Custom Carbondale Home w/Pool Near SIU!, holiday rental in Murphysboro
Peaceful Custom Carbondale Home w/Pool Near SIU!, holiday rental in Murphysboro
Peaceful Custom Carbondale Home w/Pool Near SIU!, holiday rental in Murphysboro

Peaceful Custom Carbondale Home w/Pool Near SIU!

Holiday Rental House
3 bedrooms
3 bathrooms
Sleeps 9
Match: Sleeps
More info
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Country Home for the Family, holiday rental in Murphysboro
Country Home for the Family, holiday rental in Murphysboro
Country Home for the Family, holiday rental in Murphysboro

Country Home for the Family

Holiday Rental House
4 bedrooms
5 bathrooms
Sleeps 15
Match: Sleeps
More info
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Secluded Wine Trail Getaway with Theater Room, holiday rental in Murphysboro
Secluded Wine Trail Getaway with Theater Room, holiday rental in Murphysboro
Secluded Wine Trail Getaway with Theater Room, holiday rental in Murphysboro

Secluded Wine Trail Getaway with Theater Room

Holiday Rental House
5 bedrooms
2 bathrooms
Sleeps 14
Match: Sleeps
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Beautiful apartment in a great location

Condo/Apartment
2 bedrooms
2 bathrooms
Sleeps 4
Match: Sleeps
More info
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Luxury Home in a Resort-Like Estate - Dogs Allowed!, holiday rental in Murphysboro
Luxury Home in a Resort-Like Estate - Dogs Allowed!, holiday rental in Murphysboro
Luxury Home in a Resort-Like Estate - Dogs Allowed!, holiday rental in Murphysboro

Luxury Home in a Resort-Like Estate - Dogs Allowed!

Holiday Rental House
4 bedrooms
3 bathrooms
Sleeps 8
Match: Sleeps
More info
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Large Brick Estate with pool in Quiet Neighborhood, holiday rental in Murphysboro
Large Brick Estate with pool in Quiet Neighborhood, holiday rental in Murphysboro
Large Brick Estate with pool in Quiet Neighborhood, holiday rental in Murphysboro

Large Brick Estate with pool in Quiet Neighborhood

Holiday Rental House
4 bedrooms
3 bathrooms
Sleeps 8
Match: Sleeps
More info
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NEW! Carbondale Cottage w/ Fire Pit - 3 Mi to SIU!, holiday rental in Murphysboro
NEW! Carbondale Cottage w/ Fire Pit - 3 Mi to SIU!, holiday rental in Murphysboro
NEW! Carbondale Cottage w/ Fire Pit - 3 Mi to SIU!, holiday rental in Murphysboro

NEW! Carbondale Cottage w/ Fire Pit - 3 Mi to SIU!

Holiday Rental House
2 bedrooms
1 bathroom
Sleeps 6
Match: Sleeps
More info
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1920's Farm House Built by the Trainmaster of Carbondale. Modern updates in 2012, holiday rental in Murphysboro
1920's Farm House Built by the Trainmaster of Carbondale. Modern updates in 2012, holiday rental in Murphysboro
1920's Farm House Built by the Trainmaster of Carbondale. Modern updates in 2012, holiday rental in Murphysboro

1920's Farm House Built by the Trainmaster of Carbondale. Modern updates in 2012

Holiday Rental House
4 bedrooms
2 bathrooms
Sleeps 8
Match: Sleeps
More info
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Cozy 2 bedroom Apt. in the heart of Carbondale, holiday rental in Murphysboro
Cozy 2 bedroom Apt. in the heart of Carbondale, holiday rental in Murphysboro
Cozy 2 bedroom Apt. in the heart of Carbondale, holiday rental in Murphysboro

Cozy 2 bedroom Apt. in the heart of Carbondale

Condo/Apartment
2 bedrooms
2 bathrooms
Sleeps 5
Match: Sleeps
More info
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Carbondale 2 bedroom

Holiday Rental House
2 bedrooms
2 bathrooms
Sleeps 5
Match: Sleeps
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Convenient centrally located townhouse, holiday rental in Murphysboro
Convenient centrally located townhouse, holiday rental in Murphysboro
Convenient centrally located townhouse, holiday rental in Murphysboro

Convenient centrally located townhouse

Holiday Rental House
3 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
More info
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Southern Illinois authentic 1905 cabin, holiday rental in Murphysboro
Southern Illinois authentic 1905 cabin, holiday rental in Murphysboro
Southern Illinois authentic 1905 cabin, holiday rental in Murphysboro

Southern Illinois authentic 1905 cabin

Cabin Holiday Rental
3 bedrooms
1 bathroom
Sleeps 8
Match: Sleeps
More info
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Apartment in the center of Carbondale

Condo/Apartment
2 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
More info
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NEW! Lavish Lakefront Retreat w/ Deck & Fire Pit!, holiday rental in Murphysboro
NEW! Lavish Lakefront Retreat w/ Deck & Fire Pit!, holiday rental in Murphysboro
NEW! Lavish Lakefront Retreat w/ Deck & Fire Pit!, holiday rental in Murphysboro

NEW! Lavish Lakefront Retreat w/ Deck & Fire Pit!

Holiday Rental House
5 bedrooms
7 bathrooms
Sleeps 10
Match: Sleeps
More info
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Beautiful, Upscale, and Waiting For You.  Perfect for Your 2022 Family Reunion!, holiday rental in Murphysboro
Beautiful, Upscale, and Waiting For You.  Perfect for Your 2022 Family Reunion!, holiday rental in Murphysboro
Beautiful, Upscale, and Waiting For You.  Perfect for Your 2022 Family Reunion!, holiday rental in Murphysboro

Beautiful, Upscale, and Waiting For You. Perfect for Your 2022 Family Reunion!

Holiday Rental House
4 bedrooms
4 bathrooms
Sleeps 8
Match: Sleeps
More info
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The Mediterranean is Calling! 2022 Dates Booking Fast!, holiday rental in Murphysboro
The Mediterranean is Calling! 2022 Dates Booking Fast!, holiday rental in Murphysboro
The Mediterranean is Calling! 2022 Dates Booking Fast!, holiday rental in Murphysboro

The Mediterranean is Calling! 2022 Dates Booking Fast!

Holiday Rental House
4 bedrooms
4 bathrooms
Sleeps 8
Match: Sleeps
More info
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Scenic farm house on the wine trail., holiday rental in Murphysboro
Scenic farm house on the wine trail., holiday rental in Murphysboro
Scenic farm house on the wine trail., holiday rental in Murphysboro

Scenic farm house on the wine trail.

Holiday Rental House
2 bedrooms
1 bathroom
Sleeps 6
Match: Sleeps
More info
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Amazing Log Home near Wineries, Fishing and Hiking, holiday rental in Murphysboro
Amazing Log Home near Wineries, Fishing and Hiking, holiday rental in Murphysboro
Amazing Log Home near Wineries, Fishing and Hiking, holiday rental in Murphysboro

Amazing Log Home near Wineries, Fishing and Hiking

Holiday Rental House
3 bedrooms
2 bathrooms
Sleeps 8
Match: Sleeps
More info
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Couple's Retreat with HOT TUB, holiday rental in Murphysboro
Couple's Retreat with HOT TUB, holiday rental in Murphysboro
Couple's Retreat with HOT TUB, holiday rental in Murphysboro

Couple's Retreat with HOT TUB

Holiday Rental House
1 bedroom
1 bathroom
Sleeps 2
Match: Sleeps
More info
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Wake and Bake Bud and Breakfast, holiday rental in Murphysboro
Wake and Bake Bud and Breakfast, holiday rental in Murphysboro
Wake and Bake Bud and Breakfast, holiday rental in Murphysboro

Wake and Bake Bud and Breakfast

Holiday Rental House
3 bedrooms
2 bathrooms
Sleeps 5
Match: Sleeps
More info
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Stylish 3 BR house. Downtown C'dale *BRAND NEW*, holiday rental in Murphysboro
Stylish 3 BR house. Downtown C'dale *BRAND NEW*, holiday rental in Murphysboro
Stylish 3 BR house. Downtown C'dale *BRAND NEW*, holiday rental in Murphysboro

Stylish 3 BR house. Downtown C'dale *BRAND NEW*

Holiday Rental House
3 bedrooms
1 bathroom
Sleeps 6
Match: Sleeps
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Contemporary & Charismatic 5 Bedroom Home - Booking Summer Dates Now!, holiday rental in Murphysboro
Contemporary & Charismatic 5 Bedroom Home - Booking Summer Dates Now!, holiday rental in Murphysboro
Contemporary & Charismatic 5 Bedroom Home - Booking Summer Dates Now!, holiday rental in Murphysboro

Contemporary & Charismatic 5 Bedroom Home - Booking Summer Dates Now!

Holiday Rental House
5 bedrooms
4 bathrooms
Sleeps 10
Match: Sleeps
More info
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Centrally located and family friendly., holiday rental in Murphysboro
Centrally located and family friendly., holiday rental in Murphysboro
Centrally located and family friendly., holiday rental in Murphysboro

Centrally located and family friendly.

Holiday Rental House
3 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
More info
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Upscale Designer Studio Across St from SIUC Campus, holiday rental in Murphysboro
Upscale Designer Studio Across St from SIUC Campus, holiday rental in Murphysboro
Upscale Designer Studio Across St from SIUC Campus, holiday rental in Murphysboro

Upscale Designer Studio Across St from SIUC Campus

Holiday Rental House
1 bedroom
1 bathroom
Sleeps 2
Match: Sleeps
More info
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Luxury Pine Cabin on 30 Wooded Acres, holiday rental in Murphysboro
Luxury Pine Cabin on 30 Wooded Acres, holiday rental in Murphysboro
Luxury Pine Cabin on 30 Wooded Acres, holiday rental in Murphysboro

Luxury Pine Cabin on 30 Wooded Acres

Holiday Rental House
1 bedroom
1 bathroom
Sleeps 4
Match: Sleeps
More info
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