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Spokane 's crime rate is lower than most big cities and generally safe. Travelers should take the usual precautions however. The Spokane River around the Bowl and Pitcher is very dangerous for jumping off the rocks and swimming (under-currents) with about 1 fatality a year. Even if you see others doing it avoid the temptation. Swimming in the Spokane River should be avoided all together; there are plenty of good lakes in the area.
Be sure to lock your hotel rooms and keep valuables out of sight. Simple safety measures can help you have the most enjoyable trip without any stresses.