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International travelers fly into Tocumen International Airport in Panama City. At the airport website at http://www.tocumenpanama.aero, you'll find information about arriving and departing flights, the airport facilities, the passenger services, a panorama of Panama, and business oppportunities. The site includes press releases with updated information about the airport activities, airlines and security alerts. The site has a Spanish and English versions.
From Panama City, you can fly to Isla Colon or you can drive and take a ferry. If you fly, you can take a direct flight not from Tocumen International Airport but from Albrook Airport in Panama City. It is a one-hour flight.
If you drive, you should take the Panamerican road in Panama City north to the mountains. You will need ot take the road to Chirique Grande. There, take a water taxi or you can rent a boat to Isla Colon. There a ferry service but it is not recommeneded as the trip can take as much as four hours.