Here is a link to some culture sites and English speaking venues:

A list of venues:
Berlin Tourist Info - Opera House(s) & Concert Hall(s)

Berlin's only English speaking theatre:
English Theatre Berlin

Comedy improv in English - weekly every Saturday (23:30 late show) and monthly (3rd Tues, 20:30)  
Laugh Olympics Berlin

Monthly stand up comedy show in English (20:30, 1st Tues every month) 
English Comedy Night

From June, Brighton's very own politcal satire show will be playing Berlin:
The Treason Show