From one Out-of-Towner to another (or so I'd assume), I have three words of advice: DON'T BE INTIMIDATED.
(1) Don't be intimidated by In and Out's reputation. Sometimes, as a traveler, I'm intimidated by an restaurant's reputation (e.g., Why is this place so popular? Will I know (a) how/what to order or (b) how to act/dress/etc. when I'm there?) and I allow that to influence my decision on whether to go there or not. In and Out isn't that type of restaurant -- it's not pretentious, it's not pricy, it's just a good burger and even better fries at a great price.
(2) Don't be intimidated by the crowds at In and Out. As noted above, In and Out is really popular, having a reputation that goes beyond the five states where there are restaurants (CA, UT, NV, UT, and TX). Because of that, there will no doubt be people there -- lots of people -- but the service at In and Out is fast (hence, "fast" food) and there's seating both inside and out. If you're patient, you'll find seating even during "rush hour".
(3) Don't be intimidated by In and Out's menu. It's pretty simple: hamburgers or cheeseburgers, fries, shakes and other beverages... there's even a grilled cheese option. The burgers come from one to four patties high with a special "Thousand-Island-like" sauce... but make sure to save room for the fries (which I personally believe are addictive). They're a hot and tasty, perfectly-seasoned version of old-fashioned Potato Stix plus some.
(1) Before you get there, look over the online menu and know what you want. In and Out isn't run by Seinfeld's "Soup Nazi", but it really helps to know you want. (Because there aren't lots of options, there's not a lot of time between getting in line and ordering.)
(2) There are several "Specials" combining a burger, fries and beverage. These are great options for those who want a taste of everything.
(3) We noticed a lot of "locals" who ordered some sort of special sauce -- something like the "Thousand-Island-like" burger sauce -- on their fries. We didn't order ours that way, but those who did seemed thrilled.
(4) In and Out is open late (till 1:30 am) for those who arrive at SFO after other restaurants have closed for the evening.
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