I picked this B&B largely based on reviews from this site. It's located just a block from the Santa Croce basilica, in a neighborhood that is not touristy at all. It's about a 20 minute walk to the train station, and even less than that to most spots in the old part of the city.
Mariangela is a great hostess. She helped us with recommendations for places to go and restaurant reservations.
We stayed in the La Squilla room, which has a unique design (attic room with bath down a flight of stairs). The whole place was very clean and comfortable, a great value.