Quito is such a lovely city where you can explore beautiful colonial architectural areas, Middle of the World, and dine at amazing restaurants like "Somos", "Urko", "La Purisima", "Katari", "Miskay" and others. Also from Quito you can explore incredible outdoorsy sites like Cotopaxi, Antisana, Pichincha and other amazing mountains which have beautiful fauna and flora. Last time we visited Antisana we saw a mountain lion preying on white deer, it was an incredible experience that I've never seen before in my life.
Guayaquil is a warm Florida alike weather city (always nice and warm) where you can experience less architecture and less natural sites, there is a wonderful reserve called Churute where you can watch monkeys, slots and crocodiles but we've never had the chance to go and see it.
My advice will be as a first time visitor to Ecuador to go to Quito first, from there you can see more than from Guayaquil, I'm pretty sure you will make it back to Ecuador, it is an amazing country and it is safe for tourists contrary from what you read on line. We always go back there since we have family living in Cumbaya (Quito), that suburb is something else, it has amazing vibes, architecture and dining places.
Galapagos is a paradise, we made it there last year and took a Naturalist trip in order to explore pretty much all of the islands, I can't wait to go back there in order to stay at the beach and just chill and relax during the warm season.
Ecuador is one of the most amazing countries in the world to travel and explore, enjoy it!
Edited: 15 August 2024, 08:54