On such days when I change base, I usually use the time after settling in for a stroll through the city. Sometimes I walk to sights that are closed but that I want to visit later, maybe take photos in evening light of the outside and of nice views in the city, and just so that I will be able to find it quickly when I want to go there, or to see if there is a nice eaterie nearby to combine it with... And just to get oriented in the city in general and get a feel for the vibe. On such random strolls I often come across unexpected things that are nice right there and then, or that I keep in mind for revisiting later.
In some countries museums stay open quite late, if that is the case in Prague you can make plans for that.
Or if you want a relaxed evening you could search out a local spa / bath house.
You can also leave it open and let your mood (and the weather?) decide.Edited: 01 October 2015, 06:26
Take an early morning flight and have half a day of sightseeing. Evenings are good in Prague for walking around.
Surely that depends on the time of your flight. I have travelled regularly to Prague for work and could probably make it door to door in about 4h30m.
You can also take an afternoon train from Amsterdam Centraal to Cologne from €19 booked at www.bahn.de/en and have dinner in Cologne, perhaps at the Brauhaus Sion, 10 min walk from the station. Various departures through the day.
Then take the excellent City Night Line sleeper train from Cologne (depart 22:28) to Prague Hlavni (arrive 09:25) from €60 with couchette or from €105 with a bed in a cosy 2-bed sleeper, breakfast included, shower at the end of the corridor. Also booked at www.bahn.de/en - look for the CNL train with 0 changes.
Saves a hotel bill, you get to see Cologne, it's a unique and traditional European experience, it's fun, it's centre to centre with no airport hassle. Much better option than a same-old same-old flight, and in practice doesn't even take any more time out of your schedule as it's overnight.
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