By train, times from Malpensa Aeroporto T1 to Varenna-Esino train station at http://www.trenitalia.com/tcom-en . You can buy tickets at the airport train station - validate before boarding. If you buy online, your ticket is prevalidated and therefore OK for the train purchased and for departures from the airport train station within the following three hours.
Thank you for your response.
I'm wondering if there is a car service that you know of.
Thank you again.
http://www.flytolake.com/index.php/en/ do direct bus transfers and also offer a more personalised service.
There will be lots of car transfer services who will do this run, but I have no personal knowledge of them. Google <Transfer Malpensa Varenna> to compare options, which will probably start at around €200.Edited: 10 June 2018, 22:47
We are traveling this September and I just booked FlyToLake based on this thread. Cheaper than other car services I had looked into! Thank you for the info!Edited: 13 June 2018, 05:54
I have tried to understand the Flyto Lake website but its a little confusing! I don't think they go to Varenna, which is a pity - but please anyone, let me know if you have found otherwise? Thankyou