Thanks to everyone who offered advice on here, I've just returned from a really wonderful getaway weekend in NOTL. Now that I know what a manageable weekend drive it is, we will definitely be doing more weekends there--maybe making it an annual thing, if not more frequently!
To keep things clear, I thought I'd post my notes on our weekend in a new thread instead of cluttering up the one where I originally asked for advice. I will also post reviews for the hotel, restaurants, etc. in the appropriate spots shortly.
First, hotel--we considered some of the pricier inns in town, as they all sound lovely, but then we realized we could stay at a B&B for a fraction of the price, have a lovely big breakfast each morning, personal service, and other nice touches. Why not save that extra money to bring back a few more bottles of wine! So after reading the reviews in the B&B section, I noticed there were several great options. Silken Dreams sounded like a good fit for us, & still had a room open (we were planning at short notice, so got lucky there!), so we booked with them. I'm very glad we did. I'll post more details in my hotel review, but Don & Melody were lovely hosts, and the breakfasts were amazing (and HUGE!). The room was also lovely, a nice spacious room with a king sized bed and a huge bathroom. It was a great deal.
Wine tasting: we debated about several options for tours, etc., but in the end booked a package with Niagara Classic Cabs. The package includes a private driver, tastings at 4 wineries, and lunch at the Old Angel Pub. Our driver, Richard, was wonderful--very knowledgeable about the area and the wineries. I had picked 4 wineries out from advice on here, but he asked us if we would be open to his suggestions, and once he got a sense of our tastes, he took us to a few of his choosing as well as ones I had picked (some happened to overlap, so I think I did get some great advice here, too!). In the end, we had time to fit 5 wineries in, which is definitely the most I would recommend anyone do in a day. We stopped at Reif, Riverview, Marynissen, Coyote's Run, and Ravine. Of those, the only 1 we didn't love was Reif. Nothing wrong with it, & the sensory garden was neat, but we preferred the smaller places and found we liked the wines we tasted better elsewhere (we were also offered fewer pours at Reif, & it was the only place we didn't get to pick what we wanted to taste, so that may have contributed).
For serious red wine drinkers, Coyote's Run has some fabulous wines, and tasting the difference in terroir between the Red Paw & Black Paw was neat. Ravine does as well, but they are at a higher price point--not outrageous, and we scooped up several bottles. At Marynissen we were able to do a small "vertical tasting" & compare some different vintages of the same varietal. Amazing to taste the weather conditions so clearly that way! Also, Marynissen has vineyards on 2 different types of soil just like Coyote's Run, so we taste 2 Cab Sauv's (I think--my notes aren't here with me!) from different vineyards, and the contrast there was striking as well. Despite being moderately well-educated wine drinkers, we still learned some new things and had a great day. Plus, our cellar is once again full. :-)
Food--again, I'll post more details in a review for each restaurant. The included lunch was at the Old Angel. Perfectly fine pub food, nothing exciting but good to fortify between wine stops. Dinner Friday at Stone Road was excellent, and dinner Saturday at the Old Winery was very good. Lunch today at Vineland Estates on the way back was quite good (parts were exquisite, others just good).
Spa--we had a couples massage at OSpa at the Oban Inn. Overall, a great experience. We went early because we had read that we could use the pool, hot tub, & steam room before/after our massage. It had rained heavily overnight (fortunately it was about over by the time we got to the Oban), so it wasn't really pool weather (the pool & hot tub are outdoors). The pool hadn't been cleaned post-storm (again, it had JUST stopped raining, so I can't really fault them). The hot tub didn't feel terribly hot (probably due to rain water), so we opted out of that as well. That left the steam room, which was great, but we had more time to kill than you can safely spend in a steam room! Luckily, they have a lovely "relaxation area" outside the treatment rooms where we could just lounge and drink tea. The massage itself was very good. My husband's therapist, Irmi, was exceptional. Mine (Brian) was good, but didn't quite compare to the massage therapist I have at home. Still, a nice relaxing treat for a weekend getaway.
I think that's everything! If anyone has questions about any part of our trip, please let me know. I feel like I've said a lot, but also have a nagging feeling that I may have left something out--do let me know if I have!