I would recommend that you stay in Bedfordview if you are working in the area. The traffic to Sandton is a nightmare already, and is getting worse. You can count on 1.5 to 2 hours each way drive time to be safe (may be less, but don't rely on that), and you'll be in the thick of it in both directions.
Bedfordview is a lot quiter than Sandton in terms of hotel trade, but there are some good ones (and excellent guesthouses), and a host of restaurants in the area. Infrastructure is good and safety comparable to Sandton, in my opinion.
I have to agree, I'd stick to Bedfordview. There are really good places to stay and things to do, plus as mentioned you won't have to deal with the hectic traffic.
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