White beaches, a sparkling sea, a strawberry daiquiri in hand—what more do you need in a holiday? Marco Island brings visitors the best that the Ten Thousand Islands have to offer. Scavenge for seashells or hit the links for a sunny session of golf. Explore the Everglades in a swamp buggy or enjoy a rejuvenating nature hike at the Rookery Bay Reserve.

Sitting high atop a bluff overlooking the Mississippi and Yazoo Rivers, the city of Vicksburg was the setting of a bloody 47 day siege during the Civil War. The site of this epic battle is now Vicksburg National Military Park, preserving original fortifications and the U.S.S. Cairo, an ironclad gunboat that once prowled the waters of the Mississippi River. Vicksburg is also the place where Coca-Cola was first bottled, a fact that is happily immortalized at the Biedenharn Coca-Cola Museum.

Hit the casinos, watch big-name entertainment and stay at a themed hotel. Las Vegas? No, but this small gambling town on the banks of the Colorado River offers a taste of Vegas minus the glitz, traffic and high costs. Plus, there's plenty to do here besides gambling. Not only does Laughlin have the Colorado River for boating, swimming, fishing, waterskiing and other sports, it also has gorgeous Lake Mohave offering much of the same on a grander scale. Golfers will enjoy beautiful courses where reasonable green fees stretch their cash. For a taste of the Wild West, head to nearby 100-year-old Oatman, where you can catch a mock gunfight and guzzle beer in an old-time saloon. Hiking, anyone? Grapevine Canyon awaits you, famous for the Indian markings -- some 800 years old -- carved into its boulders. You'll find plenty of gaming houses, with water shuttles running between them 24/7. What Laughlin lacks in Vegas glamour, it makes up for in affordability, scenic beauty and aquatic fun.

With the bluest of blue water and the greenest of green surrounding forest, Lake Tahoe, quite simply, transfixes. From the early Indians to authors such as Mark Twain, people have tried to capture the beauty and mystique of the lake with nicknames like "Big Blue" and "Grasshopper Soup". Others maintain that it's impossible to describe the magnificence in words. At 6225 feet above sea level, Tahoe is the highest alpine lake in the United States and has long attracted holidaymakers from around the world. In the summer, hiking, windsurfing, golfing, fishing and swimming (usually in wet suits due to the lake's brisk year-round temperature) are all the rage. The winter season starts in late November, around Thanksgiving, and brings throngs of skiers to local resorts. Located between California and Nevada, different sides of the lake tend to attract different types of visitors. The California side draws families and outdoor enthusiasts while the Nevada side beckons those looking for big-name entertainment and casinos. No matter which side you choose, a getaway to stunning Lake Tahoe will not soon be forgotten.

Most travelers come to Uyuni to visit some of the world’s most unusual terrain—the Salar de Uyuni. This is the world’s largest salt flat, and you’ll want to bring a camera for surreal photos of salt-encrusted ground, geysers, and multicolored lakes.

Kauai’s South Shore is home to some of the country’s best beaches—for swimming, diving and all sorts of water sports. If sunbathing on a gorgeous beach isn’t relaxing enough, try a spa (where many treatments incorporate local ingredients). And if you’re in Poipu for a romantic escape, splurge on an oceanview room—the sunsets are spectacular.