It’s no wonder Napa made three of our lists this year… it might just be the world’s most perfect spot for a weekend getaway. What more do you really need than romantic inns, great food and wine, and relaxing spas?

Welcome to bustling San Jose, where Silicon Valley meets Spanish history and modern edifices sit alongside meticulously restored 19th-century buildings. Such is the contrast of this city, rich in tradition and, thanks to hi-tech industry, just plain rich. Five-star hotels and fine restaurants line the streets of the restored downtown area, and the cultural scene is thriving with museums, theatre and art to rival any world-class hub. Don't miss the Tech Museum of Innovation, an exploration of Silicon Valley and its impact on the area. History buffs will relish the old mansions and can delve into the city's past at the History Museum of San Jose. Save time for a round of golf or the locals' other favourite pastime, sipping coffee and people-watching at a crowded cafe.

Here’s your day in Calistoga: Yoga. Massage. Spa lunch. Hike. Wine-tasting. Facial. Mud bath. Gourmet dinner (with more wine). Dip in a mineral pool. Does it get more relaxing than a spa town built around natural springs in the middle of wine country? We don't think so.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

You'll find crashing waves off Cabo's Pacific coast and sheltered, calm water on the Sea of Cortez. Given those options, Cabo has built a rare reputation for both excellent outdoor sports (big-game fishing, diving and kayaking, among others) and pure beach relaxation. Of course, there's also great nightlife. Cabo’s resorts, hotels and inns cater to everyone from honeymooners to families to Hollywood stars seeking a weekend getaway.

Western heritage roams freely in Fort Worth, where cattle drives occur twice a day in the Stockyards National Historic District. Enjoy diverse restaurants, exciting nightlife, cultural institutions and sporting events. Entertaining kids is a snap in the “City of Cowboys and Culture,” courtesy of Six Flags Over Texas, the Fort Worth Zoo or the Noble Planetarium and Museum of Science and History. You can depend on friendly and helpful service - the hallmark of true Texas hospitality.

It’s not just for spring-breakers. Cancun, with its golden beaches and perfect climate, is the premiere coastal destination in Mexico. And while there is certainly a 365-day party available for college students, resorts cater well to families and to those seeking solitude. This Yucatan paradise is also the gateway to the ruins of Tulum and Chichén Itzá.

Tulum is relaxation and romance with an ancient angle. Guests can enjoy modern takes on traditional Mayan massage and spa treatments, or sunbathe on gorgeous Yucatan beaches within site of well-preserved ancient ruins. A rare mix of beach, archeology and village, Tulum is a romantic getaway like no other.

The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

This canal-laced city is a far cry from its rowdy, party image of the past. Today, following renovation and renewal, upmarket stores and restaurants have replaced fast-food stands and T-shirt shops. But the city's biggest draws are its stretch of gorgeous beaches, great swimming, nearly year-round sunshine and close-to-ideal climate. For great shopping, dining and nightlife, you can't go wrong at Las Olas Riverfront, a waterfront entertainment centre with top-notch clothing and jewellery shops, bars and free entertainment. The city has a host of family-friendly options, such as Everglades Holiday Park and the Museum of Discovery and Science. With the network of canals and waterways, boats are part of the Lauderdale lifestyle, and tourists can get in on the act by hiring a boat or hailing a water taxi. There's a lot to do here, but make sure and spend some quiet time just soaking up the sun or strolling along the beach at dusk.

At the shore in Miami Beach, visitors can swim, surf and jet ski in the warm and crystal-clear Atlantic waters. You can also nap on the white sands, work on a tan or simply watch the beautiful people, especially at South Beach, a favourite of models and celebrities.

Six islands in the Florida Keys comprise the village of Islamorada, known for its prime sport fishing. Rent a boat or participate in a guided tour to fish, snorkel, or swim with marine life. Fresh seafood is the hallmark of the Islamorada dining scene. Visit a tropical-themed bar to soak in the full Florida Keys experience with a frozen umbrella drink. For a dose of culture, take in fine art and music while strolling through the Morada Way Art and Cultural District.

Get the experience of visiting two island colonies in the same 37 square miles. Saint Maarten/Saint Martin's spicy marriage of Caribbean, French and Dutch cultures matches its physical diversity: the island is both urban and untamed, with rain forest-like landscapes, white beaches, and amazing caves and wildlife.