Wild horses can actually drag you away…to Chincoteague Island. Here, ponies run wild, you can catch or dig up your own seafood, and the beaches bring literal breaths of fresh air. The Chincoteague National Wildlife Refuge is a wonderfully unspoiled spot for bird watching, horseback riding, swimming and biking. Every summer since 1925, all of the feral ponies on Assateague are rounded up for the world-famous annual Pony Swim over to Chincoteague.

Yes, Cape May is, technically, on the Jersey Shore. But it’s the antithesis of the Jersey Shore you’ll see on TV—instead of nightclubs and tanning parlors, you’ll find Victorian mansions and a famous lighthouse.

Calling itself "The Heart & Soul of the Chesapeake Bay," the town of Saint Michaels, Maryland retains the look and feel of a 19th century seaport. Walk on red brick sidewalks past the Victorian homes and boutique shops of the historic district, or head down to the pier in search of famously fresh seafood. The Chesapeake Bay Maritime Museum preserves the history of Saint Michaels, with restored examples of "bugeyes" and "skipjacks," unique boats developed by the fisherman of Chesapeake Bay.

Greenville, South Carolina, is a welcoming place to shop, dine, see historic homes and watch minor-league sports. The city is also home to significant art collections and a vibrant performing-arts scene. Families can enjoy child-friendly activities such as searching for nine bronze mice scattered around the city, visiting the Greenville Zoo, relaxing in the many outdoor spaces and enjoying numerous annual festivals. State parks and Revolutionary and Civil War sites are a short drive away.

Gulfport, Mississippi, one half of the Gulfport-Biloxi section of the Gulf Coast, was very nearly destroyed during Hurricane Katrina. The city has been gradually reconstructed, and the surrounding natural areas have been rebuilding themselves as well. Visit the barrier islands that form Gulf Islands National Seashore, a parkland along the Mississippi Sound. A ferry runs from Gulf Port to Ship Island, with unspoiled white beaches and tidal pools, boardwalks and historic sites to explore.

Seattle's petite downtown area and many attractions make it possible to pack a week’s experience into a weekend. Grab a latte and start at the world-famous Pike Place Market. Watch the fish fly and then head to the Space Needle for a dramatic view of the city and its surrounding waters. Return to earth and jump aboard a moonlit dinner cruise to Blake Island or canoe through the arbouretum.

Surrounded by one of Germany's largest wine-growing regions, Stuttgart beckons cultural junkies with its acclaimed ballet, opera and philharmonic, while car fans get revved up over the Mercedes Benz Museum. There's more green space than urban sprawl in the festival-friendly city, home to Europe's largest combined zoo and botanic garden, the Wilhelma. The Württembergisches Landesmuseum, in one of the city's oldest structures, traces the area's history from the Stone Age. Buses or metro provide handy transport.