Who cares about a little fog (okay, a lot of fog) when there’s so much to do in San Francisco? By day, explore Fisherman’s Wharf and the Aquarium of the Bay, ride a cable car, and stroll around the Presidio; by night, have a fabulous dinner (at a Michelin-starred restaurant or a tiny place in Chinatown), then hit some of the best clubs on the West Coast.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Shimmering Lake Havasu, the centerpoint of Lake Havasu City, was formed in 1938 after the Parker Dam was built. It is perhaps most famous for the London Bridge that looms above it. Yes, the actual London Bridge, bought by the area's founding father, Robert McCullough, for $2,460,000, after the city of London put it up for auction in 1968. Today, Lake Havasu City is one of the most popular holiday destinations in Arizona and offers a range of recreational activities for families, couples and single travellers. Golf on championship courses, soak up the sun on the shores of Lake Havasu's beaches or explore nearby parks by foot and bicycle. Houseboats dot the lake and are available for rent along with paddle boats, kayaks, jet skis and other types of water sports equipment. Like most resort towns Lake Havasu is chock-full of hotels, restaurants, shops and non-stop action.

Boasting rolling hills, two converging rivers, 82 parks, a sparkling lake and world class sporting facilities, Kamloops is a paradise for the active traveler. One of Canada's sunniest destinations, Kamloops enjoys on average over 2000 hours of sunshine a year and makes the perfect spot for a round of golf, a rugged bike ride through the hills or an exhilarating excursion to nearby downhill or cross country skiing facilities.

You'll find crashing waves off Cabo's Pacific coast and sheltered, calm water on the Sea of Cortez. Given those options, Cabo has built a rare reputation for both excellent outdoor sports (big-game fishing, diving and kayaking, among others) and pure beach relaxation. Of course, there's also great nightlife. Cabo’s resorts, hotels and inns cater to everyone from honeymooners to families to Hollywood stars seeking a weekend getaway.

Houston hums with an energy and independent spirit all its own. A leading cultural and culinary destination in the South, the city is home to over 11,000 restaurants featuring cuisine from more than 70 countries. The thriving arts scene includes resident opera, ballet, symphony and theatre companies. The Museum District houses 19 museums, all within walking distance. Be sure to visit Space Centre Houston, where you can visit NASA’s Historic Mission Control at the Johnson Space Centre.

Tulum is relaxation and romance with an ancient angle. Guests can enjoy modern takes on traditional Mayan massage and spa treatments, or sunbathe on gorgeous Yucatan beaches within site of well-preserved ancient ruins. A rare mix of beach, archeology and village, Tulum is a romantic getaway like no other.

It’s not just for spring-breakers. Cancun, with its golden beaches and perfect climate, is the premiere coastal destination in Mexico. And while there is certainly a 365-day party available for college students, resorts cater well to families and to those seeking solitude. This Yucatan paradise is also the gateway to the ruins of Tulum and Chichén Itzá.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

At the shore in Miami Beach, visitors can swim, surf and jet ski in the warm and crystal-clear Atlantic waters. You can also nap on the white sands, work on a tan or simply watch the beautiful people, especially at South Beach, a favourite of models and celebrities.