The first time you go to New York, go ahead and be a sight-seer—everyone should visit the Statue of Liberty, the Met, Times Square, etc. But on a return trip, pick a neighbourhood and go deep. You’ll find hole-in-the-wall bars, great delis, quirky shops… exploring the non-touristy side of New York is an incredibly rewarding experience for a traveller.

You don't have to choose between visiting a cultural capital or a sunny Caribbean beach destination—San Juan is both. This city's architecture ranges from Spanish colonial to 20th-century Art Deco, while the new Museo de Arte de Puerto Rico presents Latin American and Caribbean artwork in state-of-the-art galleries.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

Malaga, Pablo Picasso's birthplace and the gateway to the Costa del Sol, is a hectic, sometimes unruly city of 550,000. An impressive number of museums and monuments, including the 11th-century Alcazaba fort and Museu Picasso Malaga, provide plenty of diversions for those who opt not to spend all their time on the coast's famed beaches and in their accompanying bars. The old city bustles with taverns and bistros. The generous Paseo del Parque offers a delightful stroll past banana trees and fountains.

Ibiza: Old Spanish for "party 'til you drop." Perhaps not literally, but this is definitely one of Europe's favourite nightlife playgrounds. Ibiza boasts more than 100 miles of coastline with some 50 beaches, plus plenty of restaurants, bars, and water sports—and clubs, of course. Fit in a little culture and visit Ibiza's UNESCO-designated old town.

The largest city in Switzerland is a major contemporary art and shopping destination. Important artworks are displayed in the Kunsthaus and the Rietberg Museum. Those who consider shopping an art can hone their skills along Bahnhofstrasse and Niederdorf. Chagall's stained-glass windows in the Fraumünster amaze. Zurich's 500 clubs and bars, including several in swimming pools, pulse with life till the early hours. This city on Lake Zurich has excellent public transport and a free bike-hire system.

A gorgeous spot that’s a convenient day trip from Milan, Lake Como recently earned fame as home to Hollywood star George Clooney. But celeb-spotting aside, it’s known for jaw-dropping natural beauty, elegant old villas—and the scenic towns surrounding the lake. Check out Varenna, Bellagio, and Menaggio, which offer great views, historic churches, and water-based activities such as ferries and passenger-only boats.

Ecologically diverse and sparsely populated, the Big Island of Hawaii is larger than all the other better-known Hawaiian islands combined. Rental cars allow visitors to discover wonders from snow-capped mountains to rainforests to deserts. Best known for Hawaii Volcanoes National Park, home to the longest volcanic eruption in recorded history, the Big Island caters both to those who crave adventure and to those looking for luxury, with the flotilla of decadent mega-resorts dotted along Kohala Coast.

One of the most popular regions in Italy, Tuscany stretches from the Tyrrhenian Sea to the Apennines. Its main cities include Florence, Pisa, Siena, Lucca, Arezzo and Livorno. Drive between stunning sites like Florence's cathedral and Uffizi Gallery and the Leaning Tower of Pisa. Or join a bike tour and pedal past sun-baked olive groves and vineyards. Don't miss the towers of San Gimignano or serene northern hill towns. For a more modern take, hit one of Florence's hip clubs, such as Space Electronic.