Perched at the Triple Frontier, where Brazil, Paraguay and Argentina meet, Puerto Iguazu is linked to Brazil by the Tancredo Neves bridge. It is home to the Museum of Images of the Jungle, the Mborore Museum, a bird rehabilitation center and the famed Iguazu National Park. The National Park is home to 275 waterfalls, including the world-renowned Iguazu Falls, which plunges 270 feet. A subtropical climate means it's warm in winter and hot in summer, with temperatures soaring up to 104°F.

The largest city in South America, Sao Paulo’s cuisine and art is as multinational as its diverse population of 10 million. With the restaurants of the Jardins district serving every food imaginable to diners from around the world, you wouldn’t be out of place going to Sao Paulo just for the dining. But you’d be missing out on world-class museums, diverse and vibrant neighbourhood tours, and crazy-good shopping.

Writers and poets have long flourished in arts-oriented Cuenca, the country's third-largest city and the capital of the Azuay province. Cafes and galleries are tucked among the narrow cobblestone streets. The main plaza hosts both the old cathedral, started in 1557, the year the city was founded, and the blue-domed Cathedral of the Immaculate Conception, dating to 1885. Locally made Panama hats get top billing at the markets, with centrally located Casa de la Mujer a shopping standout.

With a rich pre-Colombian history, Ecuador's capital was founded on the ruins of an Incan city but offers everything a modern traveller might need. It remains the least-altered historic centre in Latin America and has been designated a UNESCO World Heritage Site. Quito’s important sites include baroque gems like San Francisco and Santo Domingo monasteries, as well as La Compañía church and college. This huge city sprawls across a breathtaking Andean valley surrounded by volcanic peaks.

La Fortuna de San Carlos is at the centre of an array of geological wonder. The nearby Arenal is Costa Rica's most active volcano, routinely bursting with lava and ash, and the Catarata de La Fortuna is a waterfall pouring from a seventy-metre cliff. The Tabacon Hot Springs are a relaxing intermission in the midst of the various spectacles, and the Leaves and Lizards Arenal Volcano Cabin Retreat is a blissful end to any day's excursion.

Hidden gems of Yucatan, such as Tulum, Akumal, Chetumal, Chichen Itza and Merida, offer an authentic taste of Mexico. Akumal and more Caribbean-style Chetumal, near the Belize border, deliver delectable white-sand beaches and great snorkelling. Merida, Chichen Itza and Tulum, with their ancient ruins, offer a passage into the Yucatan's native history. Nature lovers can jungle trek and swim in subterranean sinkholes filled with crystal-clear water. Bike around the ruins and hop between towns in colectivo vans.