Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."

More than 30 miles of beaches plus a wealth of cultural and historic institutions make this island a Gulf of Mexico holiday hot spot. If you go, don't forget your walking shoes: With 14 museums and 20 art galleries, plus several historic homes and mansions, there's a lot of ground to cover. Armchair pilots will love the Lone Star Flight Museum and those with more of a nautical interest can check out the Texas Seaport Museum. Families will enjoy the many child-friendly attractions, including Moody Gardens, with its replica of a tropical rain forest. It's easy to get caught up in all the activities, but don't forget to spend some downtime in the sun and on the beach.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

Miles of white sand and romantic island resorts beckon from the hem of the Palmetto State. Families gravitate to Myrtle Beach and the 60- mile span of Grand Strand, where over 100 championship golf courses, tennis courts and nightclubs await. Charleston's hundreds of heritage buildings and irresistible charm are part of its allure. Beach resorts at Kiawah Island, Seabrook and Edisto Island make for romantic getaways. Marshes, moss-bearded palms and oak groves create a haunting atmosphere in the Lowcountry.

This charming oceanfront community is located on the barrier island directly south of Daytona Beach, and just north of Ponce Inlet. Here oceanfront hotels offer breathtaking views of the sunrise over the Atlantic Ocean and pristine beaches to the east… and gorgeous sunsets over the Intracoastal Waterway to the west. While just a short drive away from all the excitement of Daytona Beach, this beachside retreat offers a welcome escape to travellers looking for relaxation and a little solitude.

North Carolina's coast and 300 miles of barrier island beaches are filled with lovely state parks, top restaurants and world-class golf courses. Cape Fear's beaches attract surfers. Central Wilmington contains fine antebellum homes and exciting shopping and dining. The windswept Outer Banks offer historic lighthouses, mysterious Roanoke Island and the Wright Brothers National Memorial. Cape Hatteras National Seashore offers hiking, biking and fishing. Ferry trips link islands with the mainland.

Myrtle Beach is a family-friendly beach destination—which means in addition to great beaches, there’s plenty to do when the kids are sick of making sand castles. Amusement parks, water sports and golf courses are nearby. And family-friendly dining and hotels abound.

Atlantic City draws tourists by the car- and bus-load, topping more than 20 million visitors per year! Stroll along the famous Boardwalk with its numerous amusements and eateries or visit the historic Absecon Lighthouse and the new Wheel at Steel Pier. Several championship golf courses are within a 30 minute drive to attract golf enthusiasts. In summer, the local free beaches are popular with families. Beach bars are peppered throughout the resort and you can dig your toes in the sand and enjoy your favourite cocktails. Water-based activities include parasailing, charter fishing and dolphin-watching cruises. Casino hoppers have 9 establishments to choose from and there is something for everyone's taste. Those who remember Atlantic City in its pre-gambling days can wax nostalgic with a taste of saltwater taffy and iconic rolling chairs which have been Atlantic City favourites for over 100 years.

You've got to walk the Freedom Trail the first time you visit Boston. That's just a given. Make sure you step off the line on the pavement, though, and explore some of Boston's fine museums (try the Gardner—art masterpieces displayed in their collector's mansion) and old neighbourhoods (like the North End, where you can get the best cannoli this side of Italy). You can't claim to have experienced real Boston culture, though, unless you've watched a Red Sox game from the bleachers.

The Atlantic crashes on a coastline strewn with quaint harbours, windswept beaches, glorious dunes and romantic lighthouses. Explore Cape Cod National Seashore, bike past cranberry bogs on the Rail Trail or saunter around Sandwich, the Cape's oldest town. Many areas are full of architectural and culinary gems - weathered shingles, whaling captains' mansions, chowder shacks and upmarket dining delights. Don't miss Woods Hole Oceanquest, famed Martha's Vineyard or charmingly lively Provincetown.