Everyone who visits Paris for the first time probably has the same punchlist of major attractions to hit: The Louvre, Notre Dame, The Eiffel Tower, etc. Just make sure you leave some time to wander the city’s grand boulevards and eat in as many cafes, bistros and brasseries as possible. And don’t forget the shopping—whether your tastes run to Louis Vuitton or Les Puces (the flea market), you can find it here.

Amsterdam is truly a biker’s city, although pedaling along the labyrinthine streets can get a little chaotic. Stick to walking and you won’t be disappointed. The gentle canals make a perfect backdrop for exploring the Jordaan and Rembrandtplein square. Pop into the Red Light District if you must—if only so you can say you’ve been there. The Anne Frank House is one of the most moving experiences a traveller can have, and the Van Gogh Museum boasts a sensational collection of works.

Many people travel through Frankfurt for business, as it's a major transportation hub and an industrial and financial metropolis. Of course we know that business travellers hate to have any fun on the road (wink), but it's worth lingering in Frankfurt if you can. The 2,000-year-old city has much to offer: skyscrapers, the Main River, a famous opera house, thriving theatre district, zoo, pedestrian shopping street, parks, scores of bars and dance clubs, and more than 50 museums.

The largest city in Switzerland is a major contemporary art and shopping destination. Important artworks are displayed in the Kunsthaus and the Rietberg Museum. Those who consider shopping an art can hone their skills along Bahnhofstrasse and Niederdorf. Chagall's stained-glass windows in the Fraumünster amaze. Zurich's 500 clubs and bars, including several in swimming pools, pulse with life till the early hours. This city on Lake Zurich has excellent public transport and a free bike-hire system.

Lucerne is an ancient town with strikingly modern sensibilities. One of Europe’s oldest covered bridges serves as its centrepiece, and fresco-adorned historic houses line the streets, but it’s also home to the cutting-edge KKL, a concert hall and art gallery. Take the cableways up the Pilatus, Stanserhorn or Rigi mountains for breathtaking views, or see Lake Lucerne on a steamship cruise.

We hear the question, "What’s the next Prague?" a lot. But while we’re all for discovering great new destinations, we hardly think Prague is over. Sure, everyone’s heard of it, but it’s still a grand city with extraordinary historic and cultural sights, and it’s definitely worth a visit. The often-rebuilt Prague Castle has overlooked the city since the 9th century, and the synagogues and cemetery of the Jewish Quarter are must-sees. Nightlife here is diverse and plentiful, from trendy clubs to sophisticated wine bars to late-night cellar bars.

Over 15 million gallons of water bubble daily into Budapest's 118 springs and boreholes. The city of spas offers an astounding array of baths, from the sparkling Gellert Baths to the vast 1913 neo-baroque Szechenyi Spa to Rudas Spa, a dramatic 16th-century Turkish pool with original Ottoman architecture. The "Queen of the Danube" is also steeped in history, culture and natural beauty. Get your camera ready for the Roman ruins of the Aquincum Museum, Heroes' Square and Statue Park, and the 300-foot dome of St. Stephen's Basilica.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

If you’re a history buff and a die-hard foodie, Chicago’s your kind of town. Take an architectural-history walking tour, then dine at Alinea (the most celebrated molecular-gastronomy restaurant in the U.S.). And don’t miss the Museum of Science and Industry, the biggest science museum in the Western Hemisphere.

The north Indian city of Varanasi, or Benares, is regarded as sacred by Hindus, Buddhists and Jains. Situated in the fertile Ganga valley and on the banks of the Ganges, Varanasi is a place of pilgrimage for Hindus, who come to bathe in the holy river. Known as the City of Temples and a beacon of culture, Varanasi has produced many renowned writers. It’s also a centre of silk weaving, so practise haggling at the chaotic bazaar for some beautiful souvenirs. Rickshaws are the best way to get about.