It’s nicknamed the Eternal City for a reason. In Rome, you can drink from a street fountain fed by an ancient aqueduct. Or see the same profile on a statue in the Capitoline Museum and the guy making your cappuccino. (Which, of course, you know never to order after 11 am.) Rome is also a city of contrasts—what other place on earth could be home to both the Vatican and La Dolce Vita?

Lying at Italy’s geographic and historic heart, Lazio (or Latium) was the seat of the Roman Empire, and as such is teeming with ancient attractions, especially in the Eternal City of Rome itself. To the east, Tivoli has Emperor Hadrian’s exquisite and massive Villa Adriana. Civitavecchia, today a major cruise and ferry port, has been Rome’s main harbor since the second century. Many pre-Roman sites dot Lazio too, like the Etruscan necropolis at Cerveteri, dating from the 9th century BC.

Located near the National Capital Region of Delhi, this upcoming district houses numerous multinational companies and as a result, has plenty of tourist-friendly malls, hotels and restaurants. The area's top attraction is the Sheetla Mata temple, a popular pilgrimage site named for the Indian goddess who could dispel small pox; a festival is held there in March and July. For a more rural setting, visit nearby Sohna, which is surrounded by ancient ruins and known for its hot springs.

Love garlic? You’ll love the food in Pune. Unlike other cuisines of the subcontinent, Pune cuisine relies heavily on the aromatic bulb. Soothe your palate with sweets like bhakarwadi, a pastry rolled with coriander, tamarind and sesame seeds, or cool off with a thick milkshake made with dried fruit.

The kings of the Wodeyar dynasty set the bar high for the southern cultural capital of Mysore. Ornate palaces and the Gothic St. Philomena's Church with its 175-foot spires pack a visual punch; local institutions keep Carnatic classical music and dance in the public eye. A prominent 11th-century temple sits atop 1,000 steps on the city's outskirts. Dress to the nines and party like a rock star in celebration of Mysore heritage during the lively Dussehra festival, held for 10 days in October/November.

Known as both the "Garden City" and "The Silicon Valley of India," Bangalore (officially "Bengaluru") is a techie’s paradise, boasting the highest concentration of IT companies in the country. When you’re done geeking out, there are plenty of gardens, museums, natural features, palaces and temples to fill your dance card. Visit Vidhana Soudha, Cubbon Park and the Ulsoor Lake of Bangalore, well known for its beautiful locales and boating facilities. Bangalore is also a major centre of Indian classical music and dance, and of vivid, cutting-edge nightlife.