With an age-old reputation for being a place where anything goes, Biloxi, not New Orleans, lays claim to having hosted the first party to end all parties, Mardi Gras. Today, not much has changed. Whether you're looking for fun in the sun, cultural attractions, eclectic cuisine or glittering casinos, "the playground of the South" offers the perfect mix of exciting attractions and affordable accommodation. Its prime location on the shores of the Mississippi Gulf Coast means, no matter where you are, the beach is never far away. Spend the day riding waves, jet skiing, deep-sea fishing or sailing. In addition to water sports, families will find plenty to do at local mini-golf courses, amusement parks and the aquarium. Culture-seeking landlubbers can head into town to sample a number of historical and cultural sites, such as Beauvoir, the Biloxi Lighthouse and the Ohr-OKeefe Museum. Lavish floating casinos have brought gaming, exciting nightlife and prosperity to this sultry seaside retreat.

Known as "Hub City," Hattiesburg is conveniently located at the intersection of six major US highways. More than just a stopover spot, Hattiesburg offers visitors a plethora of attractions and activities. The historic districts of Hattiesburg are some of the most intact neighborhoods in Mississippi. The Mobile Street District preserves the city's African American heritage, and the Hub City, North Main and Oaks Historic Districts feature tree-lined streets and buildings dating back to the 1880s.

Forget fashionable footwear, only your most comfortable shoes will cut it in Killarney. It's a walking town, and every trail is a history lesson. Journey on foot through Ireland's first national park, 26,000 acres of woodlands, sandstone mountains and low-lying lakes. When your feet wear out, take in Killarney National Park via boat from Ross Castle. And because there are more hotel beds in Killarney than in any other Irish town or city (besides Dublin), you'll always have a place to rest your head (and feet).