If you’re into eating locally and supporting sustainable agriculture, go to Ashville—and eat, eat, eat. This town of less than 100,000 people has 17 farmers’ markets, and the local restaurant scene is all about taking advantage of the seasonal produce sold there. And don’t miss the area’s microbreweries.

Located at the entrance to the Great Smoky Mountains National Park, Cherokee is the headquarters for the Eastern Band of Cherokee Indians. Signs around town are in English and Cherokee, and the city itself is anchored by the Harrah's Cherokee Casino. The tourist-oriented area is rich in outdoor activities for the entire family. The tribe runs a botanical garden, cultural museum, Indian village recreation, historical dramas, and an arts and crafts center.

Columbia is South Carolina's capital and home to the University of South Carolina. Along its wide avenues are historic sites ranging from an antebellum mansion to the former home of a slave who bought her freedom, plus museums, galleries, music venues, theatres and shops. Columbia's three rivers, lake, canal, national park and several city parks offer opportunities for recreation and relaxation. Child-friendly destinations include a zoo and the largest children's museum in the south.