Nestled in the fertile Susquehanna Valley, Harrisburg has played a pivotal role in the shaping of American history, both as a major link in rail and water transportation and as the setting of major Civil War battles. Having bounced back from economic distress in the 1980s, the city is now a vibrant hub of family activities, from cruises along the Susquehanna to arcades and athletics on City Island. The annual Pennsylvania Farm Show is the largest indoor agriculture exposition in the U.S.

From the National Mall’s monuments and memorials to vibrant neighbourhoods filled with character and charm, DC is a world-class destination featuring breathtaking views, award-winning hotels and hundreds of free things to do. Experience outstanding performing arts at acclaimed theatres, shop in historic Georgetown, hear great live music at legendary venues, enjoy sporting entertainment from six professional franchises and be dazzled by a flourishing dining scene with Michelin-starred restaurants.

State College, as can be imagined from its name, is a college town, the home to the main campus of Penn State, one of the ten largest public universities in the United States. Downtown State College is home to hundreds of businesses that serve the university's students and professors, from boutique shops, to coffee houses, to theaters for the performing arts. The city is also home to the Central Pennsylvania Festival of the Arts, which brings 125,000 visitors to the downtown area each year.

Saratoga Springs is one of those special escapes where everything is just, well, pretty close to perfect. The city's lovely tree-lined streets and grand old Victorian homes, porch swings swaying and gardens brimming with colourful flora, bring to mind a gentler era. World-class horse racing, renowned performing arts and natural-springs spas, plus 13 golf courses, 10 museums, a historic battlefield, fabulous boutiques, antiques and restaurants mean there is something for everyone. Relax at the Lincoln Mineral Baths, window shop in town and then it's off to the races. Walk everywhere, it's that kind of place. One of the oldest tourist destinations in the United States, Saratoga offers ample accommodation choices in elegant hotels, historic bed and breakfasts or comfortable inns. The only drawback is you may never want to leave.

Greenville, South Carolina, is a welcoming place to shop, dine, see historic homes and watch minor-league sports. The city is also home to significant art collections and a vibrant performing-arts scene. Families can enjoy child-friendly activities such as searching for nine bronze mice scattered around the city, visiting the Greenville Zoo, relaxing in the many outdoor spaces and enjoying numerous annual festivals. State parks and Revolutionary and Civil War sites are a short drive away.

Gulfport, Mississippi, one half of the Gulfport-Biloxi section of the Gulf Coast, was very nearly destroyed during Hurricane Katrina. The city has been gradually reconstructed, and the surrounding natural areas have been rebuilding themselves as well. Visit the barrier islands that form Gulf Islands National Seashore, a parkland along the Mississippi Sound. A ferry runs from Gulf Port to Ship Island, with unspoiled white beaches and tidal pools, boardwalks and historic sites to explore.

Seattle's petite downtown area and many attractions make it possible to pack a week’s experience into a weekend. Grab a latte and start at the world-famous Pike Place Market. Watch the fish fly and then head to the Space Needle for a dramatic view of the city and its surrounding waters. Return to earth and jump aboard a moonlit dinner cruise to Blake Island or canoe through the arbouretum.

Halfway between San Francisco and L.A., San Luis Obispo can be a relaxing getaway or a buzz of activity. For serenity, pack a lunch and head to one of dozens of wineries or take a drive to the beach for a leisurely swim. For a dose of history, visit the heart of the city at the beautiful Mission San Luis Obispo de Tolosa. Kids will love the Children’s Museum or Skate Park. Be sure to stroll along the creek downtown, where there are breweries, wine bars, restaurants and shopping for all tastes.