Perched at the Triple Frontier, where Brazil, Paraguay and Argentina meet, Puerto Iguazu is linked to Brazil by the Tancredo Neves bridge. It is home to the Museum of Images of the Jungle, the Mborore Museum, a bird rehabilitation center and the famed Iguazu National Park. The National Park is home to 275 waterfalls, including the world-renowned Iguazu Falls, which plunges 270 feet. A subtropical climate means it's warm in winter and hot in summer, with temperatures soaring up to 104°F.

Best known for its Festival Cervantino, an arts festival that draws attendance from around the world, Guanajuato is also a UNESCO World Heritage Site. Its old town dates back to the 16th century, and you can visit many of Mexico’s important religious and artistic sites. Guanajuato was also home to the Mexican independence movement and the site of the first failed rebellion against colonial rule.