The most famous sestiere (district) in Venice has one of the world's most famous squares, St. Mark's (Piazza San Marco). Anchored on one end by the basilica, clustered around it are restaurants, museums, shops, orchestras playing in the square, pigeons, the grand pink Doge’s Palace (Palazzo Ducale), the soaring campanile bell tower, an astrological clock tower, plus gorgeous cafes and restaurants like Florian and Quadri. Piazza San Marco is beloved by Venetians themselves. They book a table anytime, which offers a buffer from the fray. This grand outdoor drawing room attracts Venetians for a stroll too, especially late in the afternoon when the hoards of daytrippers thin out. It's simply a grand place to meet.

Castello is the largest of the six sestieri (districts), and the only one not facing onto the Grand Canal. More than half of Castello is situated within Arsenale, the naval base, which occupies over one-fifth the area of Venice. This gentrified maritime neighbourhood feels busy but casual. Castello’s side streets are laid back, with small boats lining canals criss-crossed by laundry. Semiannual exhibitions add a strong artsy current to the Arsenale area. Via Garibaldi in Castello, with its shops and bars, has one of Venice's rare straight and wide boulevards. When a large ship turns around the Lido to enter the Giudecca Canal, the startling sight creates an illusion that it will run aground right on Via Garibaldi! Families treasure Giardini near the island's tip, green with rare trees and grass, and Riva degli Schiavoni is a popular spot for Venetians to take a stroll to watch the sunset.

Artsy is the defining mood of this neighbourhood with street artists, students, painters, sculptors, restorers, curators, historians, collectors, heirs and heiresses rubbing elbows. Peggy Guggenheim's collection, now a museum, lures chic locals for evening art aperitifs. Traditionalists and visionaries cocoon in bohemian luxury. La Salute basilica buttresses the neighbourhood to the east. Gondolas bob in the morning light. The Accademia Bridge crosses the Grand Canal. A back street doubles as basketball court. Palaces house residents, or like Ca' Foscari a university, or a museum like Ca’ Rezzonico that attracts Venetians for concerts. Dorsoduro reveals its industrial roots too, in buildings converted to house university departments or exhibitions. Campo Santa Margherita bursts with youthful energy from local students. Foot traffic bustles to and from Piazzale Roma and Santa Lucia train station. Evening commuters pause for an aperitivo. Neighbours exchange confidants in a campo (square) on their way to market.

The Rialto Bridge is the most famous sight along the Grand Canal in San Polo, smallest of Venice's six sestieri (districts) and by far the busiest neighbourhood. Morning Venetians arrive to peruse the markets for fish, fruit and vegetables, while shops display goods from cheese to wine to desserts. San Silvestro and Rialto Market vaporetto (water taxi) stops add to the steady stream of foot traffic. San Polo is defined by churches including Basilica dei Frari, one of the most important churches sought by art lovers.

Giudecca is a retreat for Venetians away from the crowds. Symbolically, six metal teeth represent Venice’s six sestieri (districts); the seventh, Guidecca, points away from the others – part of Dorsoduro, but separated by the Giudecca Canal. Giudecca evolved from a center of shipyards and factories to a quiet residential area with a sprinkling of restaurants and bars. The majestic harmonious Redentore church stands as thanks for delivering Venice from the plague, hosting an annual heartfelt festival.