Julie,
I agree with Greg. The best would be to rent a car. Advise: leave early in the morning and do your sightseeing early . Start back to Memphis around 4 or 5 PM. You will be travelling on rural 2 lane roads and the roads... More
Julie,
I agree with Greg. The best would be to rent a car. Advise: leave early in the morning and do your sightseeing early . Start back to Memphis around 4 or 5 PM. You will be travelling on rural 2 lane roads and the roads are not well lit in the evenings. Best to take Hwy 55 down to Greenwood then go to BB's Museum in Indianola and then drive over to Clarksdale to the Delta Blues Museum and Ground Zero. Diagonally across of BB King's Museum is the Blue Biscuit Restaurant which has good southern food and a very friendly staff.
There are tours from Memphis, but I believe they are too steep:
Google: Delta Blues Tours....
Also, you may want to take the City of New Orleans train from Memphis to New Orleans!