In terms of location, this hotel can't be beat. My room was facing Reliant Park, and the medical center was just a few minutes away (along with related facilities). If you are visiting one of the medical facilities, they will usually call the Holiday Inn and make arrangements to give you a discounted rate (which can be substantial!). The surrounding area felt extremely safe and I saw many people going for walks right outside. The hotel shuttle will take you anywhere you need to go within 3 miles. Staff were extremely friendly and eager to help customers...when I was in the lobby I heard the concierge take several calls from people who needed various things or had requests, and they sent someone up to help immediately. I should note that, while there is a small business center in the lobby, there is only one computer (and it was being monopolized by another person while I was there). My room was very spacious and clean, and the bed was huge. The one negative thing that I do feel the need to mention is that, although the bathroom and the hallway vanity area were spotless, there was a very strong smell of mold that kind of smacked me in the face when I was in the vicinity. I almost feel badly writing about that because of how lovely the staff is at this hotel, but I think anything health/sanitation-related bears mention. Aside from that, which may not be an issue in every room, I highly recommend this hotel.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC