We stayed at Jose Antonio because the Novotel was booked up (see my Novotel review from 4/09), The hotels are comparable in price. The Jose Antonio had MUCH better internet service, a better bathroom (mostly marble), more closet space (with a light fixture) and a Jaccuzi on the 5th floor. The Novotel trumps the Jose Antonio when it comes to general ambience, room furnishings, and location. The two hotels have equally helpful staff and equally sufficient breakfasts.
The Jose Antonio was less than half full during our stay. It is my impression that the Jose Antonio does a lot of business with package tour providers. That would explain why it was so empty since Machu Picchu was closed during our stay...and Cusco in general was lacking the normal number of toursits.
I would like to reassure any VT member that if your tour provider has booked you at this hotel, it is well-run and clean. Our room on the street-side of the 6th (top) floor was a little noisy with sounds from the activity below. If you ask for a courtyard-facing room, it would probably be quieter. I've included a picture from the 6th floor looking down Av. Sol. The picture was taken early on a Sunday morning which is why there is very little traffic and the Centro Artesanal stalls (red building on the lower right) are closed.
At night, we took taxis to/from the Plazas. 5 or 6 soles. The doorman was picky about hailing taxis. He would look for taxis that are large and in excellent condition. There are a lot of very small rickety taxis in Cusco, so we appreciated his attention to this detail.
When we go back to Cusco, we will probably book the Novotel just because of proximity to excellent restaurants. But if the Novotel is full, we wouldn't hesitate to stay at the Jose Antonio.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC