We cannot say enough great things about this B&B.
Of the 4 places we stayed in the Metro region, Camila 109 was the best in every way.
The breakfast was outstanding; fresh fruit, cheese, bread, coffee. The hosts were incredibly friendly: you feel like they are friends. They suggested (not pressured) places to visit and routes to take. The room was cozy (small, yes but not a problem for us) - we had the room overlooking the terrace and city. The terrace access was great, we enjoyed a bottle of wine overlooking the city - beautiful. They allow you to use the kitchen and dishes (it really comes in handy more than you would think).
The location is great - it's close to the Pablo Neruda Museum (highly recommend visiting) and the walk down to the city and port are enjoyable. We rode the metro to Vina Del Mar to visit the beaches and museums there and it was very easy and quick to get to Vina and back.
The operation havs a "green" way about their operation: recycling and motion sensors on the bathroom sink.
HIGHLY RECOMMENDED!
Also, when touring around the city, stay within the streets on the map. We veered off the map and soon after an undesirable man told us we should be very careful or turn around...we turned around!

We had a wonderful stay at Camila 109. The host was incredibly hospitable and helpful. He helped us settle in, explained the best parts of Valparaiso to see and how to get around. The breakfast was one of the best we had in Chile, which was made even better by eating it on the balcony overlooking the city. It’s also located very close to the ‘must see’ sites. The rooms are very comfortable, clean and quite. We’d recommend it to anyone!

the hotel is a bit difficult to find if you are driving. Our GPS got confused trying to find the street. But the views from the hotel are really beautiful and the hotel owners are really helpful.

Very nice small B&B. We enjoyed our stay. From the terrace (where also breakfast is served) you have a spectacular view of Valparaiso and the ocean. Only watch out when you arrive on the 2nd of january, you might get wet, since on this special day of the year there is a tradition of making people very, very wet, ... even tourists.