The distance between this hotel and the train station, and the city center, should be key in your decision-making process. We stayed in this hotel because it was the only place we could find on relatively short-notice and we had no idea how far it was away, even though you can get to the city center in fifteen minutes of walking plus ten minutes on the metro. This hotel is also attuned more to the business travel than to tourists.
After arriving at the train station, we took the metro to the Prague Congress center. We walked from the metro stop (use the Holiday Inn's signs to help guide you part of the way) and all the way to the hotel with 40-pound bags. It is not comfortable nor convenient if you're carrying heavy bags. It's worse if you return to the congress center metro stop, as you must make the return journey uphill.
We were given a room on the top floor for three nights, with two twin beds instead of the double we asked for. We decided not to complain because we thought it would be all right, but we really should have done something; the beds are on hard wooden frames and were impossible to lay on.
The rooms were very clean and comfortable. Drawback: the carpeted floors in our room were stained, ugly, and hard.
The shower/bathtub was large and the bathroom itself very clean. Only problem was there was no above-head carriage for the shower head, so you had to hold it in your hand when you wanted to shower.
The windows in our room were skylights and while nice they did not have any shades on them to block out the sun in the morning, so that woke us up quite a bit.
There are safes in the room and three or four cabinets and a desk drawer that you can lock. There was also a refrigerator in our room (with very expensive soda and other drinks).
Breakfast is unexpectedly and gratifyingly enormous. There's more than enough to eat: cold ham, hot ham, sausage, cheeses, croissants, rolls and other pastries, cake, eggs, fruit, yoghurt, coffee, tea, juices, etc.
The breakfast room serves as a restaurant during the evening, but steel yourself for the dinner prices. It was too expensive for us.
The neighborhood around the hotel is kind of drab, but safe and relatively clean. It's rather beautiful on a clear, crisp morning. There is a store nearby where you can buy fresh fruit and vegetables, and also a bar and a 24-hour cafe/bar -- all are on the road running by the Holiday Inn that is parallel to the road that the Vysehrad is on.
The staff was okay, if a bit terse.
It was admittedly Easter weekend when we stayed here, but in our opinion we paid way too much for this hotel (well over $300 for three nights) to be so far away from the city center. We would only return to this hotel if the prices were much lower.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC