Il Granduca is in a perfect location for people visiting Florence: an easy walk to the old city center, but in a quiet area somewhat apart from the touristic hectic. The location is especially great for Americans visiting students at the Syracuse University Florence program, as it is only two blocks from the campus at Villa Rossa. It's also nice to get away from the big hotel chains and stay at a place with local character. While I was in Florence, I sprained my ankle. I was deeply touched when the owner of the hotel brought me an ice-pack and then checked on how I was doing and my needs for the remainder of my stay; it made it hurt less and made me feel less stupid. I will certainly stay at the Il Granduca anytime I return to Florence.
