I've stayed in the Art Hotel Al Fagiano two nights with my girlfriend. The Hotel is very closed to the Basilica di Sant Antonio and 5min walking to the jewish ghetto. It is an uncommon hotel, cause one of the owners is an artist, who has painted many of the pictures you can find in the rooms or into the hotel, as well as redesigned furniture. We've stayed in a white room, but there are 3 more room colour types which represents other elements. Room was very clean and bed was very comfortable. There weren't international channels or pay per view channels on the TV, but is not important. Breakfast very good for its value. The owners were very friendly and helped us suggesting many good restaurants and places to visit. I suggest it to everyone.

The hotel is located only 50 yards from St. Anthony’s and the Piazza del Santo and 25 yards from the Blue Tram/Bus stop. Very nice size, clean rooms with a bath and shower, free Wi-Fi in the lobby, a reasonably priced restaurant is attach to hotel for dinner, and they have a very friendly and helpful staff. Breakfast for additional 7 Euros was worth it and my wife and I felt very comfortable and safe wandering around the area at night.

Slept here for a night in Oct 2011. The hotel was good, the location was central. The rooms itself were clean and "funky" to say the least.
Some of the cons? Breakfast is worthless. They say breakfast included but when we got downstairs (well within the breakfast hours) there was nothing left, only gross coffee and the staff refused to make more coffee or give us breakfast.
Other then that, it was fine and it did the deal. Not amazing but not terrible either.
Would recomment.

I stayed here for two nights in June:

+ very central location next to St. Antonio cathedral and Botanical Garden
+ air condition
+ nice little garden terrace for breakfast

./. style of rooms is outdated; strange decoration
./. I chose this house because of garage facility; however, the garage is very narrow, as well as the narrow street; it takes a lot of effort and time to get into and out of the garage