Hotel Serena is situated right next to Buenos Aires which is the shopping street, and from there on you can walk to the Duomo, which might explain why it's not such a cheap hotel. The room was very small, but yet clean, and the breakfast was not bad for a 3 star hotel. I would not say that the staff are rude, they just have a sarcastic sense of humor which can be offending to some guests and others not.
Overall, Hotel Serena is a good/average hotel, and i would recommend it for short-stays.

Hotel in a really good location, nearby train station, close to the center. Not very helpful staff, the room had a really bad smell when we ariived, good only for 1 night staying. poor breakfast, not value for money!

We chose the hotel because of its location and relative good price. I have to agree with the travelers who said the staff is rude: we arrived around 7pm and we had to deal with an unbelievably rude front desk man who wouldn't reply to any of your questions politely unless you were an Italian woman in her thirties. Good thing is the front desk staff on the morning shift was nice and helpful :)

After 2 days I can tell you that the location is really good (near Stazione Centrale, half a block away from Corso Buenos Aires, walking distance from il Duomo), the rooms are fairly clean and the breakfast is good -even though it is poor, as many of the guests said-.

It's a good choice for those who are just passing by, maybe connecting trains or planes, but I wouldn't consider staying in Hotel Serena for more than 1 night.

If you`d get a euro for each rude word the employer says to the customers you cold stay there for free!!!
Beside the two spiders living in the same room the hotel was not so bad. The Breakfast is ridiculous too!
Anyway, the service was very rude and I'll never go there again! If you wanna have a nice trip in Mailand you better book another hotel!!!!