I am used to go to Hotel Mediterraneo. The reason is because It is located in my favorite area (porta Romana) and has for time to time good price offer.
Relating the Porta Romana it is worth to say taht during the day I can catch the metro and in two stops I am in the real center of Milan (duomo) and in the evening there are many restaurants, bar and a nice evening life.

POSITIVE ASPECTS: location (near metro, shopping area), very warm staff. Ask for the 5 or 6 floor with view of Duomo (really nice).
NEGATIVE ASPECTS OR TIPS:
1) sometimes is overpriced, better to check their internet discount on the net
2) you have to pay for internet and in some room dosn t works (wifi is too weak in some rooms, make sure that the room choosen has signal)
3) Breakfast tend to be no so fresh and rather basic. Instead of serving you at the coffee dispenser ask for a fresh make coffee... defenitly better
4) lifts tend to be slow expecially in the morning

I stayed at this hotel for a business trip. The hotel is of excellent quality, a few steps from Porta Romana, and therefore very convenient for travel by public transport. The rooms are comfortable, though there was a problem on the reservation, and upon arrival I was told that there were no rooms available, so I was forced to share a room with a colleague.

Decent hotel (although charging for internet access is a crime now days), fine for business, but the neighborhood is a bit far for tourists. Close to the metro (and only 2 stops from the Duomo), but not much around the area to inspire one. And have to agree with others on the cost, a bit pricey for what you get.

This is the second time I stay at this hotel and overall it is a place I would recommend . The place is clearly a bit old and probably not exactly what you would expect from a contemporary four star hotel. That said, the rooms are well kept and they are extremely clean (even though a little small). The staff is helpful and friendly.
The real hit however is the location. It conveniently located 3 minutes away from the underground and 3 tram lines. The area is also very nice, with several good restaurants and bars.
Overall I would not stay here if you are looking for a luxory experience, but it is definitely a functional place for a business trip or a short holiday. I would definitely go back next time I am in Milan.