The place seemed to have been refurbished recently. Our room was spacious with a large, comfortable bed and spacious bathroom with shower. The room, bedding and bathroom were all very clean and fresh. The breakfast was served in our bedroom and it was amazing, loads of options and home-made. The owners were very polite and helpful. The hotel is not far from the Vatican (10 min walk) and there is a tube nearby (Lepanto) which is just 2-3 stops away from the major attractions. The neighborhood isn't very touristic so it's not crowded with restaurant and other facilities but you can still find a good place to eat nearby, away from the tourist traps.

The B&B is located at the 2nd floor of a large, old building. Don't let this put you off, the rooms are very good. They also offer free wireless.

The service is great, a very nice young man was waiting for us when we arrived late and the woman who was there in the morning (and prepared the great breakfast) was very nice as well. After checkout they let us leave our bags there and gave us the key to pick them up after because there was nobody there. Thank you very much!
Big, cozy, bright, comfortable room and bed, nice, clean bathroom with towels and amenities. Free wireless internet, mini bar (cheap), TV.
It's near the Lepanto Metro and bus stop and walking distance from the Vatican.
Great value for what is offered.
I really recommend this one.
Have a nice stay!

My friend and I recently spent two weeks at the Sistine B&B. From my first encounter with Francesca through emails reserving the room, I received nothing but professional and prompt attention. A taxi was reserved for us and picked us up at the airport. The driver met us at the arrivals area and held up our names. The accommodation, location and full breakfast were excellent. They offer a substantial breakfast and you can place the order the evening before and hang the notice outside your door. As we were interested in visiting the Vatican, it was just a fifteen minute walk to the area. There is wonderful shopping just a few blocks from the B&B and the subway is just a short walk as well. Francesca and her staff were courteous and helpful at all times.
The beds were comfortable and the only negative was the sound of the garbage truck on the street early in the morning. We loved the experience of the B&B and its charming qualities. It made our first trip to Rome a wonderful experience. I would recommend this accommodation to singles and couples. Mary/Eric

The Sistine B&B was wonderful!

I definitely will recommend a B&B for the value, cleanliness, helpful staff, and proximity to attractions and public transport.

All communications from the offsite and on site staff were clear, timely, and responsive. The room was ready with beds separated for my mother and my arrival. You could eat off the floors, and the spaces and bathrooms were modern.

For half the price of a hotel I have stayed in down the street, I got an expansive breakfast (see the other write ups), free internet, and the wonderful and short interactions I like in a B&B.

I would only recommend this for a family with children, if the family took all three rooms.

The hostess-room attendant-breakfast maker-tour assistant made the difference! She greeted and explained the nuances of the property, made a unique breakfast (even soft boiled eggs) for us, and assisted in travel arrangements! A gem for the Sistine!

The B&B is in a condominium (common for Roman B&Bs) and you have to quietly walk to the second floor. This is located in a mixed district of small businesses, restaurants, and residences. I was a light sleeper the first night with the time zone change, and did wake t the late evening trash truck. I dealt with it. The elevator IS small (3 people could stand inside with small bags, but if you are a traveler with an eye for new things, it will be the source of travel stories.

I will be coming back and staying there!