What can I say, the Best Comfort B&B is one of the nicest places I've ever stayed in. The owners arranged a car transfer for us to and from the airport for a reasonable price considering our flight was late at night and it was over Easter.
There are about 5 rooms in total and although it is up a few flights of stairs (it is in what was an old palace) when you get there it is worth the short walk. The hotel really is a bargain for what you get, the rooms are light and airey and the decor is simple but effective. Everything is nice and clean, and we had a lovely view out over the buildings. The hotel is in a quiet area, located in the ghetto quarter, but is only a short walk from the Colloseu and a metro ride away from all the major sites. The owners were so lovely and accommodating, and even though we hardly spoke a word of Italian, they went out their way to make our stay enjoyable. When I was sick one day they did everything to make me comfortable, and even brought me some food after they had finished working for the night. Roma is a stunning city and the Best is worth seeking out because it's a little gem.