Stayed here for two nights recently. The hotel is on the upper levels of a shared building which is very quiet. There's enough signage to guide you through, but not really a great presence in the downstairs area.
Staff were very pleasant and all spoke English thankfully (since I didn't know much Italian).
People have commented that the rooms are small, which is true, however it was rather adequate. There was a big enough bed, a small desk and average bathroom facilities. Having been an old monastery, it was just enough for one person. The bathroom was clean, but the rug in the bedroom was a little bit tired.
Breakfast was a self-service buffet included in the price, and had the usual fare of continental, and some eggs and bacon in a chaffing dish.
From the front door, it's only a few steps away from the Vatican, so the location is excellent.
One let down was the hotel restaurant was only open for breakfast during the quiet season (winter) so you'll need to find somewhere else around the area for dinner if you're going off-peak.

This hotel is perfectly located as it is close to St. Peter's Square. I counted my steps from the gate of this hotel to the closest pillar in St. Peter's Square, it took me 20 steps and I have short legs, this would be less for someone with bigger steps. There is a lovely rooftop garden that is open from 4pm until midnight where you can have a drink and take in the view of St. Peter's Basilica and the Pope's chambers.

The ambiance of the hotel is charming, calming and does not feel like a hotel at all. There is no hustle and bustle of luggages & tourists. When you enter the lift and get to reception you feel that you have entered a quiet realm like that of a museum but then you hear beautiful classical music playing through the sound system and are warmly greeted by friendly reception staff.

This hotel is worth staying at if you are interested in being at the doorstep of St. Peter's basilica. If you want a quiet and extremely clean place to stay without ever bumping into more than 3 hotel guests at once then this is the place to stay. The hotel also provides free internet with a laptop to use. The buffet breakfast is located on the top floor in the Bernini room which is tastefully decorated.

Terrific place to stay if you want to spend time at the Vatican. Very quiet location. Rooms were very small...even by Europe standards. Shower was extremely small. Wifi was just OK. Excellent breakfast.

My husband and I enjoyed our first trip to Rome as we arrived on Oct. 22, 2010. We were fortunate to stay at the Residenza.

Not only is Residenza Paolo VI right across the street from Vatican Square, but guests may view the lighted Square at night from a convenient, charming balcony. Although we were told that "dinner" was not served at the hotel, we were served tapas, an entree, and dessert along with wine and incredible coffee. Breakfast was the most delightful array of treats. Both were served by friendly staff in a warm, inviting environment. Helping to arrange with directions, tours, and other requests, the staff was welcoming, fluent in multiple languages, and efficient.

If you wish to see the Vatican, this is the place to stay! Walk out your door, across one side street, and enter the square! What an incredible find Residenza Paolo VI was!!!!!!