The hotel is centrally located literally 2 minutes from the Barberini piazza. We (my mom and 6 year old son) stayed in an apartment in the 2nd floor. I would call it guest house or B&B than hotel. It has retained quite a lot of period features. You can look out of the bedroom window and see the row of Roman buildings (i think - as in old Rome!). The room and the hotel too for that matter requires updating - everything looks old and tired. We had booked a 2 bed apartment with kitchen facilities. Staff assistance was a bit of hit and miss! There is a small restaurant just next door to the hotel that does good food, including takeaways, at reasonable prices. The white restaurant (or some white something) around the corner, is terrible. Appearances can be deceptive as it looks great from the outside. The hop on hop off tour point is 5 minutes walk from the residence barberini. The Trevi fountain is about 10 to 15 minutes depending on your speed. Whilst it was a central location. I am not too sure if I will stay here again.

convenient location. not too much in the tourist-filled area, but a few steps away from the metro station, with almost all the famous places within walking distance. good english speaking staff with great recommendations as to groceries to go to, transportation advice, etc. roomy and clean, makes you really feel like you are living in rome.

We stayed at Residence Barberini during the half terms in October for 4 nights..
It is located very close to Piazza Barberini and walking distance to Trevi fountain (10 minutes), Colosseum (15-20 minutes), Vittore Emmanuel Monument (10-15 minutes), Pantheon (15 minutes), Piazza Navona (20 minutes)....

I know most travellers do extensive walking in Rome but we also used the limited Metro connections to reach Vatican (Ottaviano, Cipro stns), Piazza Del Popolo (Flaminio stn), Colosseum (colosseo stn) and Termini.

The residence itself is a bit dated and needs a renovation.. The rooms are spacious and there is 24 hours service (not room service)...Reception was quite helpful in dealing with all our requests. Rooms have fully equipped kitchen, LCD TV with English channels and is serviced daily..
There is no dishwasher but its not a problem and the daily service takes care of dishes. There is no washing machine/dryer but there is public laundry on via Degli Avignonesi..
Its a bit pricey but it scores heavily in terms of its central location!

There isn't a better place to stay in central Rome: quiet, large suites, very helpful and knowledgeable staff. But be cautious: I had $1500.00 stolen from my room, undoubtedly by the housekeeping staff. Of course it was denied. Yes, I should have used the safe, no doubt. My disappointment lies in the fact that the owner avoided me for four days after I reported the incident, despite promises that he would talk to me about it. This indifference put a damper on an otherwise very enjoyable visit. Moral: lock up everything valuable!