If you need to rest your head this is an average hotel. Nothing fancy about it at all. Elevators are slow and SMALL so no more than 2 people w/luggage at a time... no luggage you can fit 4. Thats about on this hotel. The breakfast was very good and a good assortment of pastries, beverages and even had bacon and eggs.

We had originially been booked to stay at another Rome hotel. After arriving at the OTHER hotel and finding it to be disgusting, we set out to find something that was several notches higher on the nice scale. From the moment we walked into Clodio we felt relieved. It was very charming and the staff was extremely accomodating. In the other hotels we had stayed in other Italian cities, the staff were nice but did not go very far out of their way to assist us in giving directions, offering advice, etc. This hotel was the complete opposite - they were so very helpful to us. Great restaurants in the area - wonderful and inexpensive Snack Bar across the street and lovely dinner restaurant one block over. Only 10-15 min walk to Vatican. Bus stop to get to all other Rome sites is only a block away. Noise level was not bad as they are located on a side street. Although they do have sound shutters to close if any noise does bother you. Careful though - they are also blackout shutters so if you don't do a wakeup call you may sleep until noon like we did! Loved this hotel, can't say enough.

I stayed in Hotel Clodio in the first weekend of October 2011 for work.
The hotel is located just below the “Montemario” hill near the headquarters of RAI.
The hotel is officially a 4 stars hotel but when you get out of the elevator I can’t find immediately my room …. My room hasn’t have the door as the others rooms because it was in renovation … so I check all the other room numbers to be sure that the horrible door was effectively my door room.
The room is quite spacious but the furniture is old and you have the sensation that all the furniture would be renovated and not only the door!!
The hotel has a nice terrace on the roof which is divided in 2 parts: on the left side you have nice sofa and low table, on the right side there are some tables and the chairs very old!! Please renovate all the terrace!! The terrace is just below the “Montemario” hill and you can see a nice view!!
The breakfast in nice with a lot of good food where you can meet some Italian TV famous people.
The hotel is not a 4 star hotel without a renovation in the rooms!!

I had the chance to stay at the Clodio hotel in Rome in September, 2011. The hotel is located in a residential area about 1.7km directly north of the Vatican. The hotel is frequented primarily by Italians and there were very few non-Italian tourists at the hotel.
The hotel is on a quiet side street and has a very unassuming front to it. The staff is quite friendly and speak English perfectly (probably other languages too). There are two different sized rooms available that I am aware of. I stayed in quite a large room that had a couch and a very large private patio overlooking the street. The rooms are very clean and well appointed in a typical European manner.
Internet WIFI is available from the hotel for 4 Euro/day.
They have a very good continental style breakfast that includes many breads, pastries, cold meats, fruit as well as scrambled eggs and ham. I am not sure if they have a full restaurant as I never checked it out. They do have a rooftop patio.
There is a breakout/conference room for groups up to 20 or 30 on the main level. There is also a bar that opens around 7PM on the main level. There is lots of couches and seating space just off of the lobby.
As far as location, it is not the most convenient to the main tourist attractions (except the Vatican). The Vatican is approximately a 20 minute walk away. Otherwise the Coliseum is over an hour walk (about 5.2km). A taxi ride is approximately 12-15 Euros to the gates of the Coliseum.
This walking will have to be your fitness regime as there is no fitness centre that I am aware of in the hotel.
I would highly recommend this hotel if you want to avoid touristy hotels. Ask for room 110 if you can get it, it is worth it.