The Sistina is perfectly located for a holiday in Rome - it's central, and all the must-see sites are easily walkable for an able bodied person.
The hotel itself is OK if you only going to use it as a base. It's quite small, and although it's faux marble decor has charm, it needs a bit of a facelift. Our room was pretty standard, with air-conditioning, a safe for personal belongings, and a spacious bathroom. Several of the reviews here say the hotel is smelly-we had no experience of any smells so cannot agree with this. The soundproofing was pretty good, considering that Rome is just about the noisiest city on earth. Parking? This is Rome-are you crazy? No chance!
Breakfast is standard continental fare, and exactly what we expected - tea, coffee, cooked meats and cheeses, cereal, croissants, juices and fruit. You can return to the buffet as many times as you want. If you're expecting a cooked breakfast go to Blackpool instead. There is a tiny roof garden where you can have breakfast served, but this information is not volunteered, you have to ask (and pay for the privilege, probably). There is no tea or coffee facility in the rooms either- this is a disappointment, and much needed after a hot day slogging around Rome. You can get room service to bring you hot drinks in the room, but this will be added to your bill. There is no restaurant for an evening meal but there are several within yards of the hotel, so it's not a problem.
The staff were generally very courteous, especially if you made the effort to speak a few basic words of Italian. Their English isn't great - but why should it be? They're italians in their own country.
A couple of tips about Rome in general:
1) Rome is not at all pushchair or wheelchair friendly. The footpaths are very narrow and bumpy, with no ramps to assist crossing the roads. Traffic is completely mental and you need to be careful. Most of the roads are cobbled and have cracks and potholes. There are lots of italians standing around chatting in groups on the streets-don't expect them to get out of your way-they won't.
2) Don't waste your money on bottled water. Buy one small bottle then top it up regularly from the waterspouts that are all over the city. The water is fresh, clean and palatable-and free!
I've stayed in many city hotels and the Sistina is as good as most, and better than some.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC