As a repeat visitors to Annecy my wife and I wanted something that was different to the 'classic' French feel (by which I mean antique furnishings, tucked into a packed city centre, and generally a little small).
In short, Clos des Sens is an ideal fit for those want something modern, tasteful and relaxed!
The hotel itself (the restaurant I will come to), is lovely. It is not big on services, no phones in rooms, laundry etc... but that is not the point - the emphasis is on cosy relaxation. The plasma tv, slate bathroom and tasteful art are a testiment to elegant modernity. The views are stunning and the rooms fabulous; a spa and fireplace in the bedroom is novel and great for those seeking a romantic getaway.
The staff are friendly and thoughtful... we were given a small package to take for our breakfast when we had an early flight and could not partake in breakfast itself.
The restaurant is outstanding... hardly the traditional tourist fare which dominates the town centre, emphasis on local ingredients but using modern techniques (foams etc). Everything a two Michelin star restaurant should be, without the sense of imposing formality.
It is a long way from the town centre, and the restaurant is an important element of the experience. If you just want to see the old town and the lake, this is not the ideal hotel/restaurant for you, although the views these rooms afford cannot be achieved without leaving the dense old town centre.
Yet for foodies and those seeking a refreshingly different French hotel Clos des Sens is a wonderful experience and I would reccomend it heartily to anyone. It is on the expensive side, but well worth it.

As a "hotel", is a perfect match to the simply stunning and delicious food from the restaurant. We stayed for 3 days for our wedding anniversary, and loved very minute.

We stayed in Room 3" on the top floor. Priviate balcony overlooking the city and lake, large jacuzzi tub in middle of room, and a very nice "rain shower" in the bathroom. I recommend it as a 'hotel' on it's own, even if you ignore the fact that you've got a a 2 Michellin star restaurant one floor below you.

But whatever you do, do *not* ignore the food! We stayed 3 days at Clos des Sens, and ate there for 2 dinners, 1 lunch, and 2 breakfasts. It was the best food experience of my life. For the quality and service you get, I found the prices actually to be a bargain, both for for the dining and the room.

Clos des Sens simply cannot be recommended highly enough for the total experience at these prices.

Clos des Sens is mostly known as an innovative, Michelin-starred restaurant whose chef, Laurent Petit, works wonders. However, they also have four rooms upstairs for those who wish to spend the night. We did and are very happy that we did. Our room had a modern décor in a red theme with dark wood finishes. The view out over the city was fabulous, especially during sunset. The bathroom had a large rain shower, and nice toiletries. And to top it off, a good-sized Jacuzzi was situated near the window in our bedroom. As nice as the room was, the reason you go to Clos des Sens is the restaurant, where we had, hands down, the single best meal of our lives. Go for the full tasting menu, and despite the price (over 100 euros per person), you will not regret it. And, after filling yourself to the limit, just take the elevator up one story and collapse on your bed or soak in your private hot tub. As a bonus, Annecy just happens to be one of the most picturesque towns in all of France.