Some of the reviews of the condition of the hotel below might be a little outdated because my stay and obvservation of the hotel is that it was perfectly nice.

Arrived into Ensenada for the first time at night. Drove down the way too touristy strip and ugly touristy hotels. At the end of the main strip was the Mision Santa Isabel, splendid mission building and rooms advertised for $49, similar to the hotels on the strip. The concierge was super friendly. The private off street parking felt very secure and at times even had a guard. My room, 212, had a king sized bed, super clean. The bed & pillows were very comfortable. The bathroom had a cool sink with a floral inlay / paint in mission style and the walls, showers, floors were all beautifully tiled. Certainly chipped in some areas, and it was not super modern, but that was its charm. And it was clean and everything worked well. Hot water was fine, shower everything worked great. The floor was refinished wood floor, perfectly nice. It had a great closet with iron clothes hangers which was really cool. The concierge helped with a lot of travel questions and since I was traveling alone, it was nice. The only con was the dining area--I had the buffet breakfast which was overpriced ($7) for what it was. Could've gotten something cheaper and tastier in town.

ENTHUSIASTICALLY RECOMMENDED!

We seldom stay on weekends, so it is usually very quiet. Ensenada is never a destination for us, but we look forward to staying there whenever we pass through Ensenada. The hotel is central to the marina district where the shops and restaurants are. The rooms are comfortable and clean. The showers have good water pressure and flow. The parking lot is secure. We enjoy talking with the hotel staff who are nice, interesting people. We usually stay there after a long drive and it is our oasis of peace, quiet and relaxation.

We had credit card guaranteed reservations for two rooms and two nights at the Hotel Mission Santa Isabel--we thought...Since we were late in leaving Phoenix, I called and spoke with the manager on Saturday to explain that we were on our way and would be there between 8-9 pm. When we arrived they had no reservations, no rooms and a very dismissive and arrogant person on the desk. He shuffled some papers on the desk and all but ignored us, then glared at us at which point we turned and left the premises. He actually said that even though I had spoken with Juan Carlos personally twice, I had the wrong hotel and it was just a "coincidence" that the hotel manager's names were the same!
The Hotel Cortez saved the day (and night) and were very sympathetic and helpful.
We are building a home in Ensenada and are traveling there frequently and will continue to do so for the next year or so. We will warn others of the problems with Santa Isabel and recommend the Hotel Cortez highly.

We just spent the weekend in Ensenada, five of us, myself, husband, daugher, son and son's girlfriend. We did not have room reservations and had stopped at two other hotels of which we inspected the rooms and inquired about prices. We found the rooms, price and location of this Hotel to be very reasonable. We had two rooms one with a king size bed and one with two queen size beds. If you like Missions, the decor will suit you, it is very much like the old Missions a lot of bulky wood decor. This Hotel offers Swedish Massages of which my son and daughter took advantage of, they really enjoyed it ($20.00 for 20 to 30 minute massage head to toe). Swimming pool is open early and closes late, there's Bar & Lounge with "Live Music" and they have their own Breakfast Buffet which is very good too. We have stayed in numerous Hotels in Ensenada and found this one to be above average. Noise of traffic is one you have to deal with no matter where you stay in Ensenada but the comfort of the beds will put you to rest. Hospitality was super.