We also stayed at the Santon for the wedding mentioned below. Hotel Santon is about a 30 minute taxi drive from Brno airport, which was quite expensive.
It should be noted that the hotel only has 17 double rooms. Most, if not all of the couples attending the same wedding as us had rooms with two single beds, that were not possible to push together. The rooms were fairly spartan, but clean, and each possessed a balcony with a view of the lake.
Breakfast overlooking the lake was especially nice, and the breakfast menu was better than at the more expensive hotel we stayed at in Prague.
Getting into Brno centre was easy enough. There's a tram stop around 150m from the hotel and all lines go into various parts of the centre.
What might put a lot of people off this hotel though is the noise. Arriving at the hotel, it looks like it will be serene and tranquil by a lake, but deep into the night music pounds from the various stands around the lake's edge. So if you fancy a quite relaxing break, Santon might not be the place to come to. Also the hotel is not air conditioned, so it might be best to stay away in the hottest months of the year also
- Santon Hotel Brno