I'm traveling alone. since 8 weeks.....and I never had any issue....;) you just need to be aware...like everywhere...cheer!
Outside of a few tough sections of Panama City and the city of Colon ( just the city not the province) Panama is pretty safe.
Just tell him not to do stupid things - no hitchhiking, don't get falling down drunk, don't wear a gold chain, no picking up local girls two at a time.
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