It's a long time since I travelled to Hurghada from Luxor but I think it was around three and a half to four hours by road (coach) with a comfort stop half way there. I can't answer your question on which resort to stay in, but you might get more responses if you ask the same question in the Hurghada forum - here is the link to that
Could I also suggest that you look at the Top Questions about Luxor section at the right hand side of this forum page, where you will find links to some cruise questions such as "Is a Nile Cruise for Me?" and "Opinions about Nile Cruises by TA Members". There's also another one you might like to read regarding star grading, plus there are others on dress code, food and lots more. On the dress code front, you'll find that this differs greatly between the Red Sea resorts and Luxor.
Luxor is a very different destination and not at all like a beach resort. It's a living, breathing, working town with many old quarters, and not like a 'purpose built' resort. I, and many others, love staying in Luxor, but it's not everyone's cup of tea - it really depends what you want from your holiday.
If you click on this link to my photo albums
you'll see one called 'Luxor street scenes' which will give you an idea of what some of the streets look like. There are other albums with photos of Luxor that you can view as well.
Another good informative website is www.luxortraveltips.com
Hope that helps for now, and happy planning!!